PMID: 9194684Jan 1, 1997Paper

Differential effects of low- and high-dose estrogen treatments on vascular responses in female rats

Life Sciences
C BolegoL Puglisi

Abstract

In an attempt to study the mechanisms by which estrogens affect vascular responses, we utilized aortic preparations from intact and ovariectomized female rats receiving low- and high-dose subcutaneous estrogen treatments. Oil-treated, as well as male rats, served as controls. In ovariectomized females, low-dose 17-beta-estradiol injections (5 microg/kg daily for two days) affected the basal release of nitric oxide, as evaluated by concentration-related curves to superoxide dismutase and N(G)-Methyl-L-arginine acetate, which was found to be greater in 17-beta-estradiol-treated females compared to oil-treated females or males. Conversely, the nitric oxide-related vascular relaxation evoked by acetylcholine and sodium nitroprusside was unchanged. Prostacyclin production was also evaluated. Aortic rings from ovariectomized 17-beta-estradiol-treated females released significantly more prostacyclin than those from oil-treated females. These results point out a possible role for nitric oxide and prostacyclin in the vascular protection brought about by physiological levels of estrogens. When intact females were treated with high doses of ethynilestradiol (100 microg/Kg daily for one month), a component of contraceptive pills, either th...Continue Reading

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Citations

Feb 27, 2001·Medicinal Research Reviews·A CignarellaL Puglisi
Aug 31, 2000·Biochemical and Biophysical Research Communications·K GhanamN Oudart
Nov 12, 2003·Respiratory Physiology & Neurobiology·Bruno DeganoRoger Escamilla
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