PMID: 3759785Sep 1, 1986Paper

Differential effects of lower body negative pressure on forearm and calf blood flow

Journal of Applied Physiology
L K EssandohJ T Shepherd

Abstract

Modest degrees of lower body negative pressure (less than 20 mmHg) cause a reflex constriction of forearm resistance vessels attributable to a decrease in activity of cardiopulmonary mechanoreceptors. In the present study, we sought to determine whether the calf vessels respond similarly. Left forearm and right calf blood flows were measured simultaneously by strain-gauge plethysmography in 10 healthy volunteers. Forearm flows decreased significantly from control during negative pressures of 10, 15, or 20 mmHg, whereas calf flows did not decrease significantly until 20 mmHg; at 10, 15, and 20 mmHg, decreases in forearm flow were significantly greater than those of the calf. Similar results were obtained in a second series of experiments in which venous pooling in the right leg during lower body negative pressure was prevented by enclosing it in a boot. At 40 mmHg, or after a Valsalva maneuver, both forearm and calf vessels constricted markedly and to the same degree. It appears that the reflex reduction in blood flow to the skeletal muscles of the limbs resulting from deactivation of the low-pressure intrathoracic mechanoreceptors is directed primarily to the arm.

Citations

Nov 1, 1992·Acta Physiologica Scandinavica·T Länne, J Lundvall
Sep 17, 2011·European Journal of Applied Physiology·Elisabeth Löberbauer-PurerErich Müller
Jun 1, 1997·Journal of Applied Physiology·H NormandP Denise
Oct 1, 1996·Medicine and Science in Sports and Exercise·J H Mitchell, R G Victor
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Oct 25, 2014·Journal of Applied Physiology·Jody L GreaneyLacy M Alexander
May 1, 1990·Circulation Research·D L KelloggW A Kosiba
Mar 27, 2001·Muscle & Nerve·A R PatelT C Chelimsky
Nov 15, 2008·Journal of Applied Physiology·Mary E J LottLawrence I Sinoway
Mar 12, 2005·Journal of Applied Physiology·Asami KitanoTakeshi Nishiyasu
Apr 19, 2002·Journal of Applied Physiology·James A Pawelczyk, Benjamin D Levine
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J A PawelczykB D Levine
May 21, 2021·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Brooke C D HockinVictoria E Claydon

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