Differential effects of m1 and m2 receptor antagonists in perirhinal cortex on visual recognition memory in monkeys.

Neurobiology of Learning and Memory
Wei WuJanita Turchi

Abstract

Microinfusions of the nonselective muscarinic antagonist scopolamine into perirhinal cortex impairs performance on visual recognition tasks, indicating that muscarinic receptors in this region play a pivotal role in recognition memory. To assess the mnemonic effects of selective blockade in perirhinal cortex of muscarinic receptor subtypes, we locally infused either the m1-selective antagonist pirenzepine or the m2-selective antagonist methoctramine in animals performing one-trial visual recognition, and compared these scores with those following infusions of equivalent volumes of saline. Compared to these control infusions, injections of pirenzepine, but not of methoctramine, significantly impaired recognition accuracy. Further, similar doses of scopolamine and pirenzepine yielded similar deficits, suggesting that the deficits obtained earlier with scopolamine were due mainly, if not exclusively, to blockade of m1 receptors. The present findings indicate that m1 and m2 receptors have functionally dissociable roles, and that the formation of new visual memories is critically dependent on the cholinergic activation of m1 receptors located on perirhinal cells.

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Citations

Jan 28, 2014·Neurobiology of Learning and Memory·Susan J BartkoTimothy J Bussey
Jan 10, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariusz ButkiewiczJens Meiler
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Patrick A ForcelliLudise Malkova
Feb 15, 2017·Journal of Cognitive Neuroscience·Patrick S Sadil, Rosemary A Cowell
Aug 24, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Etienne DjeuzongThéophile Dimo

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