Differential effects of medium- and long-chain saturated fatty acids on blood lipid profile: a systematic review and meta-analysis

The American Journal of Clinical Nutrition
Nisha PanthManohar L Garg

Abstract

Medium-chain saturated fatty acids (MCFAs) may affect circulating lipids and lipoproteins differently than long-chain saturated fatty acids (LCSFAs), but the results from human intervention trials have been equivocal. The aim of this study was to determine whether MCFAs and LCSFAs have differential impacts on blood lipids and lipoproteins. Five databases were searched (EMBASE, MEDLINE, CINAHL, Cochrane, and Scopus) until April 2018, and published clinical trials investigating the differential effects of dietary MCFAs and LCSFAs on blood lipids were included. Searches were limited to the English language and to studies with adults aged >18 y. Where possible, studies were pooled for meta-analysis using RevMan 5.2. The principle summary measure was the mean difference between groups calculated using the random-effects model. Eleven eligible crossover and 1 parallel trial were identified with a total of 299 participants [weighted mean ± SD age: 38 ± 3 y; weighted mean ± SD body mass index (kg/m2): 24 ± 2]. All studies were pooled for the meta-analysis. Diets enriched with MCFAs led to significantly higher high-density lipoprotein (HDL) cholesterol concentrations than diets enriched with LCSFAs (0.11 mmol/L; 95% CI: 0.07, 0.15 mmol/...Continue Reading

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Citations

Jan 14, 2020·Circulation·Frank M Sacks
Mar 20, 2020·Critical Reviews in Food Science and Nutrition·Camila DuartePaul F Jacques
Oct 2, 2020·DNA and Cell Biology·Vincent B LuscombeDavid R Greaves
Oct 13, 2020·Frontiers in Medicine·Keshav Raj PaudelPhilip M Hansbro
Oct 22, 2020·Critical Reviews in Food Science and Nutrition·Bárbara Júlia Fonseca VernequeCamila Kümmel Duarte
Jan 21, 2021·The American Journal of Clinical Nutrition·Marit Kolby ZinöckerSimon Nitter Dankel
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