Differential effects of myelin basic protein-activated Th1 and Th2 cells on the local immune microenvironment of injured spinal cord

Experimental Neurology
Jian-Guo HuHe-Zuo Lü

Abstract

Myelin basic protein (MBP) activated T cells (MBP-T) play an important role in the damage and repair process of the central nervous system (CNS). However, whether these cells play a beneficial or detrimental role is still a matter of debate. Although some studies showed that MBP-T cells are mainly helper T (Th) cells, their subtypes are still not very clear. One possible explanation for MBP-T immunization leading to conflicting results may be the different subtypes of T cells are responsible for distinct effects. In this study, the Th1 and Th2 type MBP-T cells (MBP-Th1 and -Th2) were polarized in vitro, and their effects on the local immune microenvironment and tissue repair of spinal cord injury (SCI) after adoptive immunization were investigated. In MBP-Th1 cell transferred rats, the high levels of pro-inflammatory cells (Th1 cells and M1 macrophages) and cytokines (IFN-γ, TNF-α, -β, IL-1β) were detected in the injured spinal cord; however, the anti-inflammatory cells (Th2 cells, regulatory T cells, and M2 macrophages) and cytokines (IL-4, -10, and -13) were found in MBP-Th2 cell transferred animals. MBP-Th2 cell transfer resulted in decreased lesion volume, increased myelination of axons, and preservation of neurons. This wa...Continue Reading

References

Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Aug 3, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S Romagnani
Nov 14, 2000·Brain Research·G A MetzK Fouad
Sep 13, 2002·Journal of Neuroimmunology·Jonathan KipnisAuraham Ben-Nur
Nov 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jonathan KipnisMichal Schwartz
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Apr 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·T Bucky JonesPhillip G Popovich
Apr 27, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Liqun YangMounir N Ghabriel
Jun 14, 2005·Journal of the Neurological Sciences·Michal Schwartz, Jonathan Kipnis
Sep 1, 2005·Clinical Reviews in Allergy & Immunology·Masaya NakamuraHideyuki Okano
Oct 26, 2005·Neuromolecular Medicine·Michael Schroeter, Sebastian Jander
Jan 3, 2007·Journal of Neuroimmunology·Sven Hendrix, Robert Nitsch
Apr 19, 2007·The European Journal of Neuroscience·Daniel P Ankeny, Phillip G Popovich
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Fernando Oneissi MartinezMassimo Locati
Jul 16, 2008·Brain, Behavior, and Immunity·He-Zuo LüPei-Hua Lu
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristina A KigerlPhillip G Popovich
Dec 17, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jian-Guo HuHe-Zuo Lü
Jul 16, 2014·Experimental Neurology·Jason R PlemelDavid P Stirling
Jun 23, 2015·Journal of Neuroscience Research·Yue-Juan ChenHe-Zuo Lü
Jul 15, 2015·ELife·Mai Nguyen-ChiFarida Djouad

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Citations

Nov 30, 2016·Journal of Neuroscience Research·Yan WuHe-Zuo Lü
Mar 24, 2017·PLoS Genetics·Kushal K DeyMatthew Stephens
Dec 13, 2018·Neural Regeneration Research·Sai-Nan WangHe-Zuo Lü
Aug 30, 2020·Neural Regeneration Research·Tian-Yun GaoBin Wang
Jan 30, 2021·Neural Regeneration Research·Jing ChenHe-Zuo Lü
Dec 12, 2020·Journal of Pain Research·Jong-Ming HsuJen-Kun Cheng

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