Differential effects of neonatal hypoxic-ischemic brain injury on brainstem serotonergic raphe nuclei

Brain Research
Hanna E ReinebrantKathryn M Buller

Abstract

Serotonergic fibres have a pervasive innervation of hypoxic-ischemic (HI)-affected areas in the neonatal brain and serotonin (5-HT) is pivotal in numerous neurobehaviours that match many HI-induced deficits. However, little is known about how neonatal HI affects the serotonergic system. We therefore examined whether neonatal HI can alter numbers of serotonergic raphe neurons in specific sub-divisions of the midbrain and brainstem since these nuclei are the primary sources of serotonin throughout the central nervous system (CNS). We utilised an established neonatal HI model in the postnatal day 3 (P3) rat pup (right common carotid artery ligation+30min 6% O2) and determined the effects of P3 HI on 5-HT counts in 5 raphe sub-divisions in the midbrain and brainstem one and six weeks later. After P3 HI, numbers of 5-HT-positive neurons were significantly decreased in the dorsal raphe dorsal, dorsal raphe ventrolateral and dorsal raphe caudal nuclei on P10 but only in the dorsal raphe dorsal and dorsal raphe ventrolateral nuclei on P45. In contrast, P3 HI did not alter counts in the dorsal raphe interfascicular and raphe magnus nuclei. We also discovered that P3 HI significantly reduces brainstem SERT protein expression; the key reg...Continue Reading

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Citations

Apr 5, 2012·Neurology Research International·Kathryn M BullerHanna E Reinebrant
Nov 14, 2012·Journal of Neuropathology and Experimental Neurology·Julie A WixeyKathryn M Buller
Dec 16, 2010·Journal of Neuropathology and Experimental Neurology·Julie A WixeyKathryn M Buller
Nov 26, 2014·Journal of Neurochemistry·Alexander DrobyshevskySidhartha Tan
Aug 26, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Niamh M DenihanDeirdre M Murray
Jan 23, 2018·Neurochemical Research·Julie A WixeyKathryn M Buller

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