PMID: 9443369Jan 1, 1997Paper

Differential effects of neuropeptide Y type 2 receptor activation on responses of rat ventral posteromedial thalamus neurons to surround vibrissae and trigeminal subnucleus interpolaris stimulation

Somatosensory & Motor Research
N L ChiaiaR W Rhoades

Abstract

Single cell recording, receptive field analysis, and microejection techniques were used to evaluate the effects of neuropeptide Y (NPY) type 2 (Y2) receptor activation on the responses of vibrissae-sensitive ventral posteromedial thalamic (VPM) neurons. Activation of this receptor with the C-terminal fragment, NPY[13-36] had no significant effect on responses evoked by deflection of principal or surround vibrissae or electrical stimulation of the trigeminal principal sensory nucleus. However, it did significantly decrease (p < 0.01) responses evoked by electrical stimulation of subnucleus interpolaris (SpI) by a mean (+/- standard error) of -31.0 +/- 8.7%). The finding that responses to surround vibrissa stimulation were not significantly decreased by a manipulation that did significantly attenuate SpI- evoked responses suggests that this nucleus is not the sole source of surround vibrissae input to VPM neurons.

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