PMID: 9004342Nov 1, 1996Paper

Differential effects of noradrenergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety

Progress in Neuro-psychopharmacology & Biological Psychiatry
Y MizukiM Yamada

Abstract

1. The appearance of frontal midline theta activity (Fm theta), the distinct EEG theta rhythm in the frontal midline area during performance of a mental task, indicates relief from anxiety in humans. 2. The authors investigated the effects of clonidine and yohimbine on anxiety and arousal in 24 male university students with (Fm theta group, n = 12) and without (non-Fm theta group, n = 12) Fm theta. Subjects received placebo, 0.15 mg clonidine and 15 mg yohimbine in a double-blind crossover design. 3. Blood samples were obtained, state-trait anxiety inventory (STAI) scores were determined, and EEGs were recorded before and during the performance of an arithmetic addition task. The test was repeated twice: before and 1 hr after drug administration. 4. Clonidine reduced the 3-methoxy-4-hydroxyphenylglycol (MHPG) concentration in both groups; yohimbine caused an increase in both groups. In the Fm theta group, clonidine reduced the appearance time of Fm theta and the number of task performance but did not alter the state anxiety scores; yohimbine had no effects on Fm theta or the state anxiety but increased the task performance. In the non-Fm theta group, clonidine increased the Fm theta amount and reduced the state anxiety score bu...Continue Reading

References

Mar 1, 1992·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Y MizukiM Yamada
Sep 1, 1988·Electroencephalography and Clinical Neurophysiology·H KuwaharaK Inanaga
Feb 1, 1989·Archives of General Psychiatry·D J Nutt
Jan 1, 1987·Psychopharmacology·S A RasmussenD S Charney
Jul 1, 1972·Electroencephalography and Clinical Neurophysiology·T Ishihara, N Yoshi
Jun 1, 1982·Archives of General Psychiatry·R Hoehn-Saric
Aug 1, 1980·Electroencephalography and Clinical Neurophysiology·Y MizukiK Inanaga
Jan 1, 1984·Folia Psychiatrica Et Neurologica Japonica·Y MizukiM Yamada

❮ Previous
Next ❯

Citations

Apr 6, 2013·Psychopharmacology·Alan C SwannF Gerard Moeller
Nov 19, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Bradley S FolleySohee Park
Dec 18, 2001·Pharmacology & Therapeutics·S W TamM Wyllie
Jan 6, 2006·Journal of Experimental Psychology. Learning, Memory, and Cognition·Andrei C MiuMircea Miclea
Jul 26, 2006·Anesthesia Progress·David L HallJohn D Walters
Jul 22, 2008·Brain Research·Gennady G KnyazevJaroslav Yu Slobodskoj-Plusnin
May 4, 2005·Biological Psychiatry·Alan C SwannF Gerard Moeller
May 14, 2016·Brain Research·Gennady G KnyazevJulia M Rimareva
Jun 25, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Ian M Colrain
Nov 9, 2000·European Journal of Ophthalmology·J WeindlerK W Ruprecht
Oct 1, 2008·Progress in Neurobiology·Damon J MitchellIan J Kirk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.