PMID: 15232495Jul 3, 2004Paper

Differential effects of norepinephrine on brain and other less vital organs detected by a multisite multiparametric monitoring system

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Ari KrautAvraham Mayevsky

Abstract

Under emergency situations, the protection of the most vital organs in the body, the brain and the heart, may result in a decrease in tissue perfusion, mitochondrial dysfunction and energetic failure, in "less-vital" organs (skin, G-I tract, kidney etc.). One of these pathways includes the secretion of epinephrine and norepinephrine. The aim of the present study was to test the effect of norepinephrine injection on the vitality of four different organs (vital and "less-vital") monitored simultaneously. The four organs monitored were, the brain- a vital organ and three "less vital" organs-the kidney, liver and testis. The vitality of the organs was evaluated by monitoring the levels of microcirculatory tissue blood flow (TBF) and the level of mitochondrial NADH measured from the surface of each organ. The hemodynamic state, TBF, was monitored by the laser Doppler flowmetry (LDF) and the metabolic state was evaluated by surface fluorometry-reflectometry. The results indicated that following norepinephrine bolus injection the increase in mean arterial pressure (MAP) was associated with an increase in cerebral blood flow and a decrease in all three "less vital" organs TBF. As a result, NADH levels in the brain remained stable where...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Communicative & Integrative Biology
Martial Depczynski, Monica Gagliano
© 2022 Meta ULC. All rights reserved