Differential effects of oxycodone and venlafaxine on resting state functional connectivity-A randomized placebo-controlled magnetic resonance imaging study

CNS Neuroscience & Therapeutics
Tine Maria HansenJens Brøndum Frøkjaer

Abstract

Different mechanisms may be involved in the antinociceptive effects of oxycodone (opioid) and venlafaxine (serotonin-norepinephrine reuptake inhibitor), and the aim of this study was to investigate the effect of these drugs on brain functional connectivity. Resting state functional magnetic resonance imaging was acquired in 20 healthy volunteers before and after a 5-day treatment with oxycodone, venlafaxine, or placebo in a randomized, double-blind, crossover study. Functional connectivity analyses were performed between four predefined seeds (dorsal anterior cingulate cortex, rostral anterior cingulate cortex, posterior insula, and prefrontal cortex), and the whole brain. The overall interpretation was that there were differences between the effects of oxycodone and venlafaxine on functional connectivity. Oxycodone mainly showed decreased functional connectivity between limbic structures and to supralimbic areas (all P < 0.05). Venlafaxine also showed decreased functional connectivity between limbic structures and to supralimbic areas, but increased functional connectivity to structures in the midbrain and brain stem was also found (all P < 0.05). Oxycodone and venlafaxine showed differential effects on resting-state functiona...Continue Reading

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Citations

Nov 28, 2020·Cellular and Molecular Neurobiology·Cherkaouia KibalyCatherine M Cahill
Apr 9, 2021·Peptides·Richard J Bodnar
Jul 2, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Suganthiya S CroosuTine M Hansen
Aug 25, 2021·British Journal of Clinical Pharmacology·Tine Maria HansenAsbjørn Mohr Drewes

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