Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells

Molecular Medicine Reports
Pengfei BaQinfeng Sun

Abstract

The extracellular signal-regulated protein kinase 1/2 (Erk1/2) and p38 mitogen‑activated protein‑kinase pathways serve important roles in the regulation of osteogenic and chondrogenic differentiation in mesenchymal stem cells (MSCs). However, the exact mechanism remains unclear, and the effect is controversial. In the present study, the effects of Erk1/2 and p38 on the osteogenic and chondrogenic differentiation of dental pulp stem cells (DPSCs) were compared in vitro. The results indicated that inhibition of Erk1/2 is able to enhance the osteogenic differentiation of DPSCs and inhibit chondrogenic differentiation, whereas inhibition of p38 demonstrated the opposite effect. When compared with previous studies, the present study further confirmed that Erk1/2 and p38 serve important, but complicated, roles in regulating the differentiation of MSCs. Different chemical and physical stimuli, cell types, culture methods, times of inhibitor administration and the dosage of the inhibitor may influence the effect of Erk1/2 and p38 on the differentiation of MSCs. The present study aims to better understand the mechanisms that control the differentiation of MSCs and may be helpful in creating more effective tissue regeneration.

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Citations

Apr 5, 2019·Acta Biochimica Et Biophysica Sinica·Ting ZhangWeiliang Zhu
Feb 19, 2020·Oral Diseases·Jiaqi ZhuHong He
Feb 19, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jianmei LiShiwu Dong
Dec 14, 2019·Journal of Orthopaedic Surgery and Research·Ning MaPeng Chen
May 22, 2019·International Journal of Molecular Sciences·Krista Minéia WartchowPatrícia Sesterheim
Jul 10, 2021·Frontiers in Cell and Developmental Biology·Bo LiYi Men
Sep 30, 2021·Molecular Medicine·Senxiang ChenSen Qin

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Methods Mentioned

BETA
protein assay
X-ray

Software Mentioned

SPSS

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