PMID: 3213839Dec 1, 1988Paper

Differential effects of partial hepatectomy on hepatic and renal heme and cytochrome P450 metabolism

The American Journal of the Medical Sciences
K SolangiR D Levere

Abstract

Partial hepatectomy has been suggested to affect hepatic and renal cytochrome P450 content and the related drug metabolizing enzyme system. In addition, cytochrome P450 and its dependent activities have been shown to be regulated by the availability of cellular heme. We, therefore, studied cytochrome P450 in addition to the level of heme oxygenase, the rate-limiting enzyme of heme catabolism, and delta-aminolevulinic acid (ALA) synthase, the rate-limiting enzyme of heme synthesis, in the remnant liver and intact kidneys of rats after two-thirds hepatectomy. The level of hepatic heme oxygenase was elevated threefold in partially hepatectomized rats as compared to sham-operated rats, while ALA synthase was decreased by 40%. This was reflected in decreased hepatic cytochrome P450 content, ie, from 0.689 +/- 0.175 nmole/mg to 0.505 +/- 0.089 nmole/mg protein and associated decreased drug metabolizing enzymes: aryl hydrocarbon hydroxylase, 7-ethoxycoumarin-O-deethylase, and benzphetamine N-demethylase, by 40%, 40%, and 47%, respectively. In contrast, renal heme oxygenase was not changed after hepatectomy, whereas renal ALA synthase was increased by fourfold. Renal cytochrome P450, aryl hydrocarbon hydroxylase, 7-ethoxycoumarin-O-dee...Continue Reading

References

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Citations

Jan 1, 1997·European Journal of Drug Metabolism and Pharmacokinetics·A M MazaJ L Pedraz
Nov 25, 2003·Prostaglandins & Other Lipid Mediators·David SacerdotiJohn C McGiff
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nancy Kelley-LoughnaneJorge A Bezerra
Mar 23, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·David J TaberRoshan Shrestha
Mar 23, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James F TrotterGregory T Everson
Nov 6, 2008·World Journal of Gastroenterology : WJG·Giovanni Li VoltiFabio Galvano
Aug 14, 2001·Biochemical and Biophysical Research Communications·V TamásiK Monostory
Jan 9, 1998·Drug Metabolism Reviews·E T Morgan
Mar 9, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Constantino FondevilaJuan C García-Valdecasas
Jul 1, 1991·Journal of Hepatology·M J TuñonJ Gonzalez
Jun 30, 2016·Prostaglandins & Other Lipid Mediators·David SacerdotiMassimo Bolognesi
Aug 1, 2002·Current Protocols in Toxicology·N G AbrahamA Goodman
Aug 17, 2004·World Journal of Gastroenterology : WJG·Cun-Shuan XuJing-Bo Zhang
Jun 1, 1990·Biochemical Medicine and Metabolic Biology·R MametA Atsmon

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