Differential effects of prenatal cocaine and retinoic acid on activity level throughout day and night

Pharmacology, Biochemistry, and Behavior
M W Church, J P Tilak

Abstract

Prenatal cocaine exposure is associated with disrupted state control and lowered activity levels. Prenatal retinoic acid excess also influences activity levels in laboratory rats. Activity level is usually monitored during a brief period in young offspring. The effects of these drugs on pup activity levels throughout the day is unknown. There is also little information on the long-lasting effects of these teratogens in adult animals. We compared the daily activity of rats which were prenatally exposed to cocaine or retinoic acid (RA). Appropriate control groups were also used. The offspring were evaluated for activity levels in a neophobic situation and for a 22-h period in same-sex groups of 3 littermates. As both pups and adults, the cocaine groups were hypoactive while the RA group was hyperactive when first placed into the testing cage (neophobic situation). Similarly, during the remainder of the 22-h testing period, the pup and adult cocaine animals exhibited reduced activity levels while the RA animals exhibited elevated activity levels. Thus, prenatal cocaine and retinoic acid exposures affected offspring activity levels differently, both drugs have long-lasting neurobehavioral effects that persist into adulthood, and ef...Continue Reading

References

Sep 21, 1979·Science·C V VorheesR E Butcher
Sep 1, 1992·Journal of the American Academy of Child and Adolescent Psychiatry·G A RogenessS R Pliszka
Apr 24, 1992·Brain Research. Developmental Brain Research·H M Akbari, E C Azmitia
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D R WeaverS M Reppert
Nov 5, 1992·The New England Journal of Medicine·Z N KainE M Scarpelli
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·J PerisW J Millard
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·A C ZmitrovichS Church
Nov 1, 1992·Neurotoxicology and Teratology·C J HeyserL P Spear
Nov 1, 1992·Neurotoxicology and Teratology·G A GoodwinL P Spear
Aug 1, 1992·Physiology & Behavior·B Zimmerberg, M S Gray
Mar 1, 1992·Developmental Psychobiology·C L MagnanoB Z Karmel
Jan 1, 1992·Neurotoxicology and Teratology·C J HeyserL P Spear
Mar 1, 1992·Neurotoxicology and Teratology·J W Schneider, I J Chasnoff
Aug 6, 1992·The New England Journal of Medicine·J J Volpe
Jun 28, 1992·Annals of the New York Academy of Sciences·J S Meyer
May 1, 1992·Neurotoxicology and Teratology·J S MeyerN R Macdonald
Nov 1, 1991·Neurotoxicology and Teratology·W S WebsterH E Ritchie
Sep 1, 1991·Physiology & Behavior·S L JoutsiniemiM L Laakso
Jan 1, 1991·Life Sciences·M F Seifert, M W Church
May 1, 1991·Neurotoxicology and Teratology·H E HughesD L Dow-Edwards
Aug 1, 1991·Child Development·B M LesterH L Golub
Dec 15, 1990·Brain Research. Developmental Brain Research·D L Dow-EdwardsT A Fico
Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·S K SobrianL M Turner
Jul 1, 1990·Neurotoxicology and Teratology·M W Church, G W Overbeck
Sep 1, 1989·Pediatric Neurology·M C SpiresR Chan
Jan 1, 1989·Neurotoxicology and Teratology·R F SmithS L Kurtz
Jan 1, 1989·Neurotoxicology and Teratology·L P SpearN E Spear
Jan 1, 1989·Neurotoxicology and Teratology·D E HutchingsD L Dow-Edwards
Jul 1, 1988·Neurotoxicology and Teratology·M W ChurchP K Gessner
Jan 1, 1988·Neurotoxicology and Teratology·M W ChurchP K Gessner
Oct 1, 1987·The Journal of Pediatrics·A S Oro, S D Dixon
Sep 12, 1985·The New England Journal of Medicine·I J ChasnoffK A Burns
Jul 30, 1969·Annals of the New York Academy of Sciences·V H Denenberg
Dec 1, 1984·European Journal of Pediatrics·W KiessR Haas

❮ Previous
Next ❯

Citations

Mar 10, 2004·Pharmacology, Biochemistry, and Behavior·Melanie P McFadyen-LeussisRichard E Brown
Mar 25, 1998·Pharmacology, Biochemistry, and Behavior·M W ChurchP A Holmes
Dec 7, 2000·Neurotoxicology and Teratology·S J GlattD Jackson
Aug 10, 1999·Neurotoxicology and Teratology·R R HolsonS A Ferguson
Jul 21, 1998·Annals of the New York Academy of Sciences·M W ChurchJ P Tilak
Apr 30, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Lenka TomášováDarina Kluchová
Aug 13, 2003·The European Journal of Neuroscience·P J McCafferyE Rosa-Molinar
Dec 12, 2012·Annals of Neurology·Wengang WangNigel S Bamford
Jun 1, 1998·Annals of the New York Academy of Sciences·Michael W ChurchJacqueline P Tilak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.