PMID: 8959039Oct 31, 1996Paper

Differential effects of prenatal exposure to cocaine and amphetamine on growth parameters and morphometry of the prefrontal cortex in the rat

Annals of the New York Academy of Sciences
M A Tavares, M C Silva

Abstract

The purpose of this study was to investigate the differential effects of prenatal exposure to psychostimulants, e.g., cocaine or amphetamine, on basic growth parameters and morphometry of the medial prefrontal cortex of the rat. A group of pregnant Wistar rats was given 60 mg/kg body weight/day of cocaine hydrochloride and another group 10 mg/kg body weight/day of d-amphetamine sulfate, subcutaneously, from gestational days 8 to 22. Control groups of pregnant rats were pair-fed; litters were culled to eight pups (4 males and 4 females) weighed every other day until postnatal day 30 and every week until day 90. The body weight growth patterns modelled by a Gompertz curve were different in rats prenatally exposed to the two psychostimulants. Rats exposed to amphetamine had on average a slower growth than those exposed to cocaine, reaching an identical estimated adult weight. Allometric relationships between forebrain and body weight and cerebellum and body weight were described by two distinct postnatal growth phases that are different among the experimental groups. In the comparison of the two psychostimulants the relative cerebellum/body growth is lower in the offspring of the cocaine group than in the amphetamine group between...Continue Reading

References

Jan 1, 1978·Bulletin of the World Health Organization·M R HillemanA F Woodhour
Jul 1, 1978·Pharmacology, Biochemistry, and Behavior·A G Nasello, O A Ramirez
Apr 24, 1992·Brain Research. Developmental Brain Research·H M Akbari, E C Azmitia
Jul 1, 1990·Neurotoxicology and Teratology·M W Church, G W Overbeck
Nov 15, 1985·The Journal of Comparative Neurology·C G Van Eden, H B Uylings
Jan 1, 1989·Annals of the New York Academy of Sciences·D L Dow-Edwards
Aug 1, 1987·European Journal of Clinical Microbiology·W CullmanW Dick
Oct 1, 1986·Journal of Neuroscience Methods·H Braendgaard, H J Gundersen
Nov 15, 1985·The Journal of Comparative Neurology·C G Van Eden, H B Uylings
Oct 1, 1965·Physiological Reviews·S Brutkowski
Mar 16, 1984·European Journal of Pharmacology·S D Glick, P A Hinds
Jul 1, 1995·Neurotoxicology and Teratology·M C SilvaM A Tavares
Apr 1, 1993·Teratology·D A HaringM L Kwee
Feb 1, 1993·Experimental Eye Research·A Silva-AraújoM A Tavares
Mar 1, 1993·Teratology·C A KimmelJ Chen
Aug 1, 1995·Molecular Neurobiology·A Silva-AraújoM A Tavares
Aug 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M A TavaresS F Ali

❮ Previous
Next ❯

Citations

May 1, 2005·Environmental Toxicology and Pharmacology·Ana MagalhãesLiliana de Sousa
Jun 19, 2008·Neurotoxicology and Teratology·Andrew M SmithWei-Jung A Chen
Jul 18, 2006·Brain Research·Pedro MeloMaria Amélia Tavares
Dec 8, 2011·Brain Research·M BergheimN Dafny
Sep 6, 2005·Human & Experimental Toxicology·C Q MoreiraE G Moreira
Nov 16, 2006·Annals of the New York Academy of Sciences·Lorena G RodriguesMaria Amélia Tavares
Aug 22, 2009·Journal of Speech, Language, and Hearing Research : JSLHR·Lucie MénardJohanna-Pascale Roy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.