Differential effects of rapid eye movement sleep deprivation and immobilization stress on blood lymphocyte subsets in rats

Neuroimmunomodulation
J Velazquez-MoctezumaRocio Ortiz-Muñiz

Abstract

There is growing evidence of the relationship between sleep and the immune response. Studies aimed at elucidating the function of rapid eye movement (REM) sleep have found it difficult to separate the effects due to REM sleep deprivation and the effects due to the stress produced by the deprivation procedure. It has been claimed that immobilization is the main stressor that the animals have to face during the deprivation process. In this study, we analyzed the effects of short-term (24 h) and long-term (240 h) REM sleep deprivation on the distribution of lymphocyte subsets in the peripheral blood of rats. In addition, these effects were compared with those obtained after both short- and long-term stress by immobilization. Lymphocyte population bearing surface markers such as CD5 (T cells), CD45RA (B cells), CD4 (T helper/inducer cells), CD8 (T suppressor/cytotoxic cells) and CD161 (NK cells) were analyzed using monoclonal antibodies. Lymphocyte subsets were assessed by flow cytometry. Both short- and long-term REM sleep deprivation decreased the percentage of T lymphocytes and induced a significant increase in NK cells. Short-term immobilization induced only a significant increase in the percentage of B lymphocytes and a decrea...Continue Reading

Citations

Aug 4, 2010·Medical Hypotheses·V KahanS Tufik
May 8, 2007·Sleep Medicine Reviews·Ruben Victor RialSusana Esteban
Jul 25, 2012·Annals of the New York Academy of Sciences·Beatriz Gómez-GonzálezJavier Velázquez-Moctezuma
Dec 21, 2005·Neuroscience Letters·María J NúñezManuel Freire-Garabal
Jul 26, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ethem GelirLamia Pinar
May 2, 2015·Psychoneuroendocrinology·Beatriz H P De LorenzoDeborah Suchecki
Dec 25, 2013·Clinical & Developmental Immunology·Gabriela Hurtado-AlvaradoBeatriz Gómez-González

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