PMID: 6781323Mar 1, 1981Paper

Differential effects of Renografin-76 on the ischemic and nonischemic myocardium

The American Journal of Cardiology
H YamazakiR H Helfant


The effects of intracoronary diatrizoate meglumine and diatrizoate sodium (Renografin-76) on regional contraction were examined in the normal coronary circulation and during partial (50 percent) coronary occlusion in 11 dogs using strain and length gauges. Intracoronary injections of Renografin-76 (1.5 cc) (1.690 mosM/liter; 0.19 mEq Na/ml), equiosmolar dextrose solution and 0.19 mEq Na+/ml saline solution were made randomly. Renografin-76 caused a decrease in preejection tension to 87.4 +/- 4.3 percent (p less than 0.025), total tension to 74.6 +/- 3.3 percent (p less than 0.01) and ejection tension to 11.9 +/- 12.6 percent (p less than 0.001) of control value. Segment length increased to 106.7 +/- 7.3 percent of control value. These changes lasted only 12 +/- 2 (range 5 to 20) seconds (mean +/- standard error of the mean). During partial coronary occlusion and after injection of Renografin-76, preejection tension decreased from 91.7 +/- 6.3 to 53.8 +/- 3.9 percent (p less than 0.01), total tension from 89.9 +/- 5.0 to 59.7 +/- 3.5 percent (p less than 0.01) and ejection tension from 22.8 +/- 8.1 to 17.8 +/- 10.9 percent, whereas segment length increased from 112.7 +/- 3.7 to 130.7 +/- 4.6 percent (p less than 0.01) of control...Continue Reading


Aug 1, 1977·The American Journal of Cardiology·V S BankaR H Helfant
Jan 1, 1975·Japanese Heart Journal·H YamazakiY Nakamura
Jun 2, 1966·The New England Journal of Medicine·A Benchimol, E M McNally
Jan 1, 1970·The American Journal of Cardiology·N GootmanN M Buckley
May 1, 1965·Circulation·G C FRIESINGERR S ROSS

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