Differential effects of restrictive and malabsorptive bariatric surgery procedures on the serum lipidome in obese subjects

Journal of Clinical Lipidology
Bruno Ramos-MolinaFrancisco J Tinahones

Abstract

Bariatric surgery (BS) is the most effective treatment for severe obesity. Our group and others have previously reported that the type of BS (restrictive vs malabsorptive) can lead to different effects on the lipid profile and glucose homeostasis in morbidly obese patients. Furthermore, BS exerts significant changes in lipid metabolism, which are not yet fully understood and that might be dependent of surgical technique. The objective of this study was to evaluate the differential changes in the serum lipidomic profile of morbidly obese subjects who underwent two different BS techniques: sleeve gastrectomy (SG) (restrictive) and biliopancreatic diversion (BPD) (malabsorptive). This study included 37 morbidly obese patients (body mass index ≥ 40 kg/m2) who underwent either SG (n = 25) or BPD (n = 12). Serum lipid extracts were assessed at baseline and 6 months after BS and were analyzed in a ultra-high performance liquid chromatography time-of-flight mass spectrometry-based platform. SG not only restores the circulating levels of fatty acids and glycerolipids to similar levels to those observed in nonobese subjects but also results in a consistent increase of phospholipid and sphingolipid species, ranging from antioxidant plasma...Continue Reading

Associated Clinical Trials

Citations

Mar 19, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Stephanie Sik Yu SoHani El-Nezami
Nov 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ivan LiakhAdriana Mika
Apr 3, 2020·Seminars in Pediatric Surgery·Petter BjornstadDaniel van Raalte
Dec 3, 2021·Reviews in Endocrine & Metabolic Disorders·Matilde VazMariana P Monteiro

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