Differential effects of serotonin reuptake inhibitors fluoxetine and escitalopram on bone markers and microarchitecture in Wistar rats

European Journal of Pharmacology
Manoj KumarDivya Vohora

Abstract

Evidence from several studies indicates that the long-term treatment of selective serotonin reuptake inhibitors (SSRIs) is associated with a decrease in bone mass and increase the risk of fractures. The present work evaluated and compared the effect of treatment with two SSRIs viz. fluoxetine and escitalopram on bone biomarkers (P1NP and βCTX) in male Wistar rats. In addition, the effect of these drugs on bone microarchitecture of lumbar and tibia bones was carried out. Fluoxetine (8.2 mg/kg) treatment for 40 days significantly reduced (P < 0.01) the levels of the P1NP while escitalopram (2.0 mg/kg) was without such effects. Both drugs were devoid of any effects on bone resorption marker βCTX. The pCREB levels were reduced by both the antidepressants but the reduction was significantly (P < 0.001) marked in case of fluoxetine. The micro-CT data revealed that fluoxetine, but not escitalopram, treatment resulted in reduced bone volume fraction, trabecular thickness and number while increased trabecular separation, trabecular pattern factor and connectivity density in the proximal tibial metaphysis. No significant changes were, however, discernible in lumbar bones. The study shows that fluoxetine reduces bone formation possibly th...Continue Reading

References

Oct 28, 2005·The New England Journal of Medicine·J John Mann
Oct 17, 2006·Journal of Cellular Biochemistry·R BattaglinoP Stashenko
Jan 30, 2007·Bone·L V HaleA G Geiser
Jun 27, 2007·Archives of Internal Medicine·Elizabeth M HaneyUNKNOWN Osteoporotic Fractures in Men Study Group
Aug 23, 2007·Psychopharmacology·Meredith A FoxDennis L Murphy
Jan 26, 2008·Calcified Tissue International·Peter VestergaardLeif Mosekilde
Aug 30, 2008·Menopause : the Journal of the North American Menopause Society·Stuart J WardenCharles H Turner
Feb 25, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M W M van den BrandF de Vries
Oct 6, 2010·The Journal of Cell Biology·Patricia Ducy, Gerard Karsenty
Dec 25, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S VasikaranUNKNOWN IOF-IFCC Bone Marker Standards Working Group
May 3, 2011·Journal of Psychiatric Research·Hasan AydinNaz Berfu Gunel Akbas
Sep 10, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Q WuM D Crowell
Jun 5, 2012·Bone·R RizzoliP Vestergaard
Nov 15, 2012·Investigative Ophthalmology & Visual Science·Gülgün TezelRobert Ritch
Feb 27, 2013·Indian Journal of Psychiatry·Sandeep GroverKamla Deka
Aug 21, 2013·Clinical Therapeutics·Charles F Seifert, Tara R Wiltrout
Dec 3, 2013·Bosnian Journal of Basic Medical Sciences·Elma Kučukalić-SelimovićAlmira Hadžović-Džuvo
Jul 12, 2014·The Journal of Clinical Endocrinology and Metabolism·Susan J DiemBenjamin Z Leder
Jul 22, 2014·Journal of the American Geriatrics Society·Marie Anne GebaraEric J Lenze
Nov 22, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Vivian Bradaschia-CorreaPhilipp Leucht
Jun 1, 2017·Osteoporosis and Sarcopenia·Ravisha WadhwaDivya Vohora

❮ Previous
Next ❯

Citations

Jul 4, 2018·International Journal of Environmental Research and Public Health·Julietta Ursula SchweigerEva Fassbinder
Apr 20, 2019·Psychiatry Research·Manoj KumarDivya Vohora

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

JAMA : the Journal of the American Medical Association
Gillian Elizabeth MeadMaree Hackett
International Braz J Urol : Official Journal of the Brazilian Society of Urology
Fikret ErdemirErkan Sogut
Therapeutische Umschau. Revue thérapeutique
A KochH Tschäppeler
© 2022 Meta ULC. All rights reserved