Differential effects of sevoflurane and propofol anesthesia on left ventricular-arterial coupling in dogs

Acta Anaesthesiologica Scandinavica
Y L DeryckS Brimioulle

Abstract

General anesthetics interfere with arterial and ventricular mechanical properties, often altering left ventricular-arterial (LVA) coupling. We hypothesized that sevoflurane and propofol alter LVA coupling by different effects on arterial and ventricular properties. Experiments were conducted in six anesthetized open-chest dogs for the measurement of left ventricular pressure and aortic pressure and flow. Measurements were performed during anesthesia with 0.5, 1.0 and 1.5 minimum alveolar concentration sevoflurane and 12, 24 and 36 mg/kg/h propofol. LVA coupling was assessed as the ratio of ventricular end-systolic elastance (E(es), measuring ventricular contractility) to effective arterial elastance (E(a), measuring ventricular afterload). The steady component of afterload, arterial tone, was assessed by systemic vascular resistance and arterial pressure-flow curves. The pulsatile component of afterload was assessed by aortic impedance and compliance. Sevoflurane decreased aortic pressure and cardiac output more than propofol. Sevoflurane reduced arterial tone, increased arterial stiffness and did not affect wave reflections. It increased E(a), decreased E(es) and reduced LVA coupling. Propofol reduced arterial tone, did not af...Continue Reading

References

Nov 1, 1977·The American Journal of Cardiology·K SagawaK M Bakalar
Mar 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·I D CockshottP J Simons
Jan 1, 1992·Anesthesia and Analgesia·P F ConzenK Messmer
Oct 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P J SimonsR J Ruane
Jan 1, 1988·British Journal of Anaesthesia·M A ClaeysF Camu
Apr 1, 1987·Computers and Biomedical Research, an International Journal·R BurattiniS Fioretti
Jul 1, 1985·Medical & Biological Engineering & Computing·D N Stone, J P Dujardin
Jun 1, 1980·IEEE Transactions on Bio-medical Engineering·K SunagawaY Nose
Oct 1, 1994·Anesthesia and Analgesia·T KawasakiS Takahashi
Nov 1, 1996·Anesthesia and Analgesia·Y L DeryckR Naeije
Jan 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Serge BrimioulleRobert Naeije

❮ Previous
Next ❯

Citations

Sep 17, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Christos V IoannouDenis R Morel
Nov 23, 2011·Acta Anaesthesiologica Scandinavica·J R LarsenJ M Hasenkam
Mar 21, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Christian VollmerAlexander M Mathes
Nov 13, 2013·Journal of the American Animal Hospital Association·Janan M AbedBenjamin M Brainard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.