Differential effects of simvastatin on IL-13-induced cytokine gene expression in primary mouse tracheal epithelial cells.

Respiratory Research
Amir A ZekiReen Wu

Abstract

Asthma causes significant morbidity worldwide in adults and children alike, and incurs large healthcare costs. The statin drugs, which treat hyperlipidemia and cardiovascular diseases, have pleiotropic effects beyond lowering cholesterol, including immunomodulatory, anti-inflammatory, and anti-fibrotic properties which may benefit lung health. Using an allergic mouse model of asthma, we previously demonstrated a benefit of statins in reducing peribronchiolar eosinophilic inflammation, airway hyperreactivity, goblet cell hyperplasia, and lung IL-4 and IL-13 production. In this study, we evaluated whether simvastatin inhibits IL-13-induced pro-inflammatory gene expression of asthma-related cytokines in well-differentiated primary mouse tracheal epithelial (MTE) cell cultures. We hypothesized that simvastatin reduces the expression of IL-13-inducible genes in MTE cells. We harvested tracheal epithelial cells from naïve BALB/c mice, grew them under air-liquid interface (ALI) cell culture conditions, then assessed IL-13-induced gene expression in MTE cells using a quantitative real-time PCR mouse gene array kit. We found that simvastatin had differential effects on IL-13-mediated gene expression (inhibited eotaxin-1; MCP-1,-2,-3; an...Continue Reading

References

Sep 2, 2003·Journal of Leukocyte Biology·De YangJoost J Oppenheim
Oct 27, 2004·American Journal of Respiratory and Critical Care Medicine·Sang-Heon ChoSebastian L Johnston
Dec 14, 2004·American Journal of Respiratory and Critical Care Medicine·Michael B FesslerG Scott Worthen
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·James K Liao, Ulrich Laufs
Apr 28, 2006·Nature Reviews. Immunology·John GreenwoodScott S Zamvil
May 26, 2006·Journal of Dental Research·K SakodaY Izumi
Dec 16, 2006·European Journal of Pharmacology·Dae Yong KimJai Youl Ro
Apr 17, 2007·Nature Medicine·Georgina XanthouVily Panoutsakopoulou
Aug 4, 2007·American Journal of Respiratory and Critical Care Medicine·Stacey E AlexeeffJoel Schwartz
Dec 13, 2007·The Journal of Allergy and Clinical Immunology·Stephen T Holgate
Jan 22, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Desmond M MurphyJames L Lordan
Jan 23, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Stephen T Holgate
Nov 5, 2008·The Journal of Clinical Investigation·Peter J Barnes
Feb 24, 2009·American Journal of Respiratory and Critical Care Medicine·Davina C M SimoesChristina Gratziou
Jun 2, 2009·International Journal of Toxicology·Noriho SakamotoStephan F van Eeden
Jul 18, 2009·American Journal of Respiratory and Critical Care Medicine·Amir A ZekiNicholas J Kenyon
Sep 2, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Daniel J SchneiderMichael R Blackburn
Nov 12, 2009·The Journal of Biological Chemistry·Sasa VukelicMarjana Tomic-Canic
Jun 8, 2010·American Journal of Respiratory Cell and Molecular Biology·Anna DvorakRonald G Crystal
Jun 19, 2010·American Journal of Respiratory Cell and Molecular Biology·Tanveer AhmadAnurag Agrawal
Jun 22, 2010·The European Respiratory Journal·K SamitasM Gaga
Aug 21, 2010·American Journal of Respiratory Cell and Molecular Biology·Jeremy A HirotaDarryl A Knight
Sep 2, 2010·Thorax·Vasiliki DelimpouraStelios Loukides
Sep 24, 2010·Thorax·Douglas C CowanD Robin Taylor
Nov 17, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Amir A ZekiNicholas J Kenyon
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Weihua WangDaya Upadhyay
Jun 1, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S KonnoS-K Huang

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Citations

Jul 2, 2014·American Journal of Respiratory and Critical Care Medicine·Sze Man Tse, Ann Chen Wu
Jul 25, 2014·Drugs·Rachid Berair, Christopher E Brightling
Oct 6, 2014·Immunology and Allergy Clinics of North America·Angela L LinderholmNicholas J Kenyon
Jan 24, 2014·Current Medical Research and Opinion·Amir A Zeki
Sep 12, 2015·Journal of Immunology Research·Paul M PeetersNiki L Reynaert
Jan 18, 2015·Pulmonary Pharmacology & Therapeutics·Neil C ThomsonCharles McSharry
Jun 15, 2014·Pulmonary Pharmacology & Therapeutics·Katie E BakerLyn M Moir
Nov 4, 2016·International Forum of Allergy & Rhinology·Eun Jung LeeKyung-Su Kim
Jul 15, 2016·Annals of Biomedical Engineering·N Higuita-CastroS N Ghadiali
Dec 1, 2015·Pulmonary Medicine·Dipanjan BhattacharjeeRahul Magazine
May 24, 2016·Expert Opinion on Drug Delivery·Alaa S TulbahDaniela Traini
Mar 4, 2017·Journal of Periodontal Research·M R MessoraM Taba
Mar 27, 2018·Expert Review of Respiratory Medicine·Amir A Zeki, Mona Elbadawi-Sidhu
Sep 21, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Derrica Y Walker, Krystal L Edwards
Nov 13, 2018·Current Opinion in Pulmonary Medicine·Diana E Amariei, Robert M Reed

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Methods Mentioned

BETA
lavage
dissection
PCR
GTPase
biopsies

Software Mentioned

Prism

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