Differential Effects of Strong and Regular Statins on the Clinical Outcome of Patients With Chronic Kidney Disease Following Coronary Stent Implantation - The Kumamoto Intervention Conference Study (KICS) Registry

Circulation Journal : Official Journal of the Japanese Circulation Society
Masanobu IshiiKumamoto Intervention Conference Study (KICS) Investigators

Abstract

The aim of this study was to examine the effects of different statins on the clinical outcomes of Japanese patients with coronary stent implants. This study included 5,801 consecutive patients (males, 4,160; age, 69.7±11.1 years, mean±SD) who underwent stent implantation between April 2008 and March 2011. They were treated with a strong statin (n=3,042, 52%, atorvastatin, pitavastatin, or rosuvastatin), a regular statin (n=1,082, 19%, pravastatin, simvastatin, or fluvastatin) or no statin (n=1,677, 29%). The patients with chronic kidney disease (CKD) were divided into mild-to-moderate CKD (30≤eGFR<60, n=1,956) and severe CKD (eGFR <30, n=559). Primary endpoints included cardiovascular death and nonfatal myocardial infarction, including stent thrombosis and ischemic stroke. The clinical outcome for the primary endpoint in mild-to-moderate CKD patients treated with a strong statin (hazard ratio 0.50, 95% confidence interval 0.31-0.81; P=0.005) was significantly lower than in those on no statins, but that in the patients treated with a regular statin was not (P=0.160). The clinical outcome for the primary endpoint in severe CKD patients treated with a strong or regular statin was no different than not being on statin therapy (P=0....Continue Reading

References

Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Oct 29, 2003·Circulation·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Nov 8, 2003·Hypertension·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Mar 5, 2004·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN REVERSAL Investigators
Mar 10, 2004·The New England Journal of Medicine·Christopher P CannonUNKNOWN Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators
Mar 10, 2005·The New England Journal of Medicine·John C LaRosaUNKNOWN Treating to New Targets (TNT) Investigators
Jul 22, 2005·The New England Journal of Medicine·Christoph WannerUNKNOWN German Diabetes and Dialysis Study Investigators
Oct 19, 2006·Cleveland Clinic Journal of Medicine·Ilke SipahiSteven E Nissen
Oct 24, 2007·Circulation·Kristian ThygesenNawwar Al-Attar
Apr 12, 2008·Journal of the American College of Cardiology·James ShepherdUNKNOWN TNT (Treating to New Targets) Investigators
Apr 1, 2009·The New England Journal of Medicine·Bengt C FellströmUNKNOWN AURORA Study Group
Dec 2, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Tadasuke ChitoseUNKNOWN Kumamoto Intervention Conference Study (KICS) Investigators
Mar 27, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahiro NatsuakiUNKNOWN CREDO-Kyoto PCI/CABG registry cohort-2 investigators
Jul 13, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuhiro DanHiroshi Ito
Sep 1, 2012·The American Journal of Cardiology·Masahiro NatsuakiUNKNOWN CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators
Mar 29, 2013·Circulation. Cardiovascular Imaging·Koji KatoIk-Kyung Jang
Sep 27, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Wijtske Annema, Arnold von Eckardstein
Nov 19, 2013·Journal of the American College of Cardiology·Neil J StoneUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Aug 30, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Si Van NguyenKiyotaka Kugiyama

❮ Previous
Next ❯

Citations

Jul 25, 2015·Expert Review of Cardiovascular Therapy·Vasilios G AthyrosAsterios Karagiannis
Jan 5, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Kenichi TsujitaHisao Ogawa
Nov 20, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Jeong Hoon YangSeung-Hyuk Choi
Aug 21, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Yusaku ShimboToyoaki Murohara
Apr 17, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Stephen J Nicholls, Yu Kataoka
Jun 7, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Kensuke MatsushitaKazuo Kimura
Jan 27, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daisuke SuetaSeiji Hokimoto
May 22, 2016·Journal of the American Heart Association·Masanobu IshiiHisao Ogawa
Jan 7, 2020·Clinical and Experimental Nephrology·Yusuke UemuraUNKNOWN N-registry investigators
Jun 4, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Masanobu IshiiKenichi Tsujita

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.