Differential effects of tactile high- and low-frequency stimulation on tactile discrimination in human subjects.

BMC Neuroscience
Patrick RagertHubert R Dinse

Abstract

Long-term potentiation (LTP) and long-term depression (LTD) play important roles in mediating activity-dependent changes in synaptic transmission and are believed to be crucial mechanisms underlying learning and cortical plasticity. In human subjects, however, the lack of adequate input stimuli for the induction of LTP and LTD makes it difficult to study directly the impact of such protocols on behavior. Using tactile high- and low-frequency stimulation protocols in humans, we explored the potential of such protocols for the induction of perceptual changes. We delivered tactile high-frequency and low-frequency stimuli (t-HFS, t-LFS) to skin sites of approximately 50 mm2 on the tip of the index finger. As assessed by 2-point discrimination, we demonstrate that 20 minutes of t-HFS improved tactile discrimination, while t-LFS impaired performance. T-HFS-effects were stable for at least 24 hours whereas t-LFS-induced changes recovered faster. While t-HFS changes were spatially very specific with no changes on the neighboring fingers, impaired tactile performance after t-LFS was also observed on the right middle-finger. A central finding was that for both t-LFS and t-HFS perceptual changes were dependent on the size of the stimulate...Continue Reading

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Citations

Feb 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Claudia WilimzigHubert R Dinse
Jun 23, 2010·BMC Neuroscience·Claudio A PerezLeonel E Medina
Nov 20, 2012·Experimental Brain Research·Amanda L KaasRainer Goebel
May 28, 2014·The European Journal of Neuroscience·Eva-Maria ReuterBen Godde
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Feb 1, 2012·Vision Research·Kristoffer C Aberg, Michael H Herzog
Mar 15, 2015·Frontiers in Computational Neuroscience·Petra RitterRichard Kempter
Dec 6, 2014·Frontiers in Human Neuroscience·Na Jin SeoPilwon Hur
Nov 22, 2014·Frontiers in Human Neuroscience·Vito Enrico Pettorossi, Marco Schieppati
Jun 4, 2016·Archives of Gerontology and Geriatrics·Ana Isabel VieiraAlexandre Castro-Caldas
Aug 3, 2017·Proceedings of the National Academy of Sciences of the United States of America·Caroline A Lea-CarnallLaura M Parkes
Oct 31, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Roberto ErroKailash P Bhatia
Jul 26, 2019·Cerebral Cortex·Masato HiranoShinichi Furuya
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Mar 3, 2020·Developmental Psychobiology·Daniil P AksenovAlexander Drobyshevsky
Dec 13, 2017·Neural Plasticity·Stefanie HebaTobias Schmidt-Wilcke
Jun 13, 2020·Frontiers in Human Neuroscience·Fabian Timm, Esther Kuehn
Jan 18, 2019·Nature Communications·Marion BrickweddeHubert R Dinse
May 16, 2020·Frontiers in Neuroscience·Hiraku WatanabeHideaki Onishi
Nov 8, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Roberto ErroLorenzo Rocchi
Nov 10, 2020·IScience·Caroline A Lea-CarnallLaura M Parkes
Apr 28, 2021·Clinical Neurology and Neurosurgery·Fatemeh AyoobiMahdieh Azin

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