PMID: 8971797Nov 22, 1996Paper

Differential effects of tetrodotoxin (TTX) and high external K+ on A and C fibre compound action potential peaks in frog sciatic nerve

Neuroscience Letters
S BuchananJ R Elliott

Abstract

Monophasic compound action potentials were recorded from Rana sciatic nerves. Three distinct peaks were observed and designated A alpha, A delta and C. All peaks were abolished by replacement of the external medium with Na(+)-free solution. However, the C peak alone was unaffected by external application of 1 microM tetrodotoxin (TTX), both A peaks were completely suppressed. The C peak was also the most resistant to chronic depolarization caused by increased external K+. K+ (17.6 mM) solution reduced peak areas to 5 +/- 4, 27 +/- 11 and 63 +/- 14% of control for A alpha, A delta and C components. The C peak was therefore Na(+)-dependent, TTX-resistant and K(+)-depolarization resistant. These attributes are similar to those described for somatal TTX-resistant Na+ channels in other species. But, application of 1 microM TTX to a K(+)-depolarized nerve caused a further reduction in C peak area, suggestive of a voltage-dependent block by TTX similar to that reported for cardiac muscle Na+ channels.

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D T Campbell
May 1, 1992·Anesthesia and Analgesia·D M GaumannP Jirounek
Jun 1, 1990·Pflügers Archiv : European journal of physiology·R EickhornH Antoni
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Citations

Nov 28, 2012·Experimental Brain Research·Jonas TesarzSiegfried Mense
Oct 2, 2002·Neuroscience Research·Eike D Schomburg, Heinz Steffens
Feb 5, 2000·Regional Anesthesia and Pain Medicine·D S KohaneC B Berde
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·G F LopreatoH H Zakon
Dec 13, 2006·The Journal of Physiology·Anthony M RushStephen G Waxman
Feb 1, 2007·Anesthesiology·Alberto J Rodriguez-NavarroFrancisco Alvarez
Jul 20, 2000·The Journal of Biological Chemistry·J M McIntoshB M Olivera
Apr 2, 1998·European Journal of Anaesthesiology·M E Bräu, J R Elliott
Feb 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Monika Sundqvist

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