PMID: 16629418Apr 25, 2006Paper

Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures

Multiple Sclerosis : Clinical and Laboratory Research
Robert P LisakD Skundric

Abstract

Cytokines secreted within the central nervous system (CNS) are important in the development of multiple sclerosis (MS) lesions. The balance between Th1, monocyte/macrophage (M/M) and Th2 cytokines in the CNS may be pivotal in determining the outcome of lesion development. We examined the effects of mixtures of cytokines on gene expression by CNS glial cells, as mixtures of cytokines are present in MS lesions, which in turn contain mixtures of glial cells. In this initial analysis by gene array, we examined changes at 6 hours to identify early changes in gene expression that represent primary responses to the cytokines. Rat glial cells were incubated with mixtures of Th1, M/M and Th2 cytokines for 6 hours and examined for changes in early gene expression employing microarray gene chip technology. A minimum of 814 genes were differentially regulated by one or more of the cytokine mixtures in comparison to controls, including changes in expression in a large number of genes for immune system-related proteins. Expression of the proteins for these genes likely influences development and inhibition of MS lesions as well as protective and regenerative processes. Analysing gene expression for the effects of various combinations of exog...Continue Reading

References

Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G S EisenbarthM Nirenberg
Sep 1, 1992·Journal of Neuroscience Research·M V GardinierJ M Matthieu
Jul 1, 1991·Journal of the Neurological Sciences·M P PenderJ F Kerr
Mar 1, 1991·The Journal of Clinical Investigation·K SelmajC F Brosnan
Oct 1, 1987·Journal of Neurochemistry·E N BenvenisteJ N Whitaker
Jun 1, 1988·Journal of Neuroimmunology·E LaviS R Weiss
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R P SanetoJ de Vellis
Apr 1, 1988·Annals of Neurology·K W Selmaj, C S Raine
Jan 1, 1985·Springer Seminars in Immunopathology·P Dore-DuffyM Longo
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L A SternbergerN H Sternberger
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B RanschtW Seifert
Dec 1, 1993·Journal of Neuroscience Research·J A IdaR D McKinnon
Apr 1, 1995·Annals of Neurology·B Cannella, C S Raine
Jan 1, 1995·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·S R Barnum
Mar 1, 1995·Journal of Neuroscience Research·D G WalkerP L McGeer
Jan 1, 1994·Journal of Neuropathology and Experimental Neurology·E UlvestadJ Antel
Jul 1, 1996·Brain Pathology·C F Brosnan, C S Raine
Oct 1, 1996·The Journal of Experimental Medicine·P DowlingW Husar
Dec 1, 1995·Brain, Behavior, and Immunity·S C LeeC F Brosnan
Dec 1, 1996·The Journal of Experimental Medicine·S D D'SouzaJ P Antel
Jan 1, 1997·Microbiology and Immunology·H AkatsuH Okada

❮ Previous
Next ❯

Citations

Oct 25, 2017·Journal of Molecular Neuroscience : MN·Dominika Ksiazek-WiniarekAndrzej Glabinski
Feb 1, 2011·Neurochemical Research·Joyce A BenjaminsRobert J Sokol
Jun 4, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A A SemkinaM B Abadzhyan
May 30, 2009·Journal of Neuroscience Research·Jason J RoseJoyce A Benjamins
Sep 7, 2017·Journal of Neuroscience Research·Joyce A BenjaminsRobert P Lisak
Oct 3, 2007·Regenerative Medicine·Robert H Miller, Lianhua Bai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved