Differential effects of the new antipsychotic risperidone on sleep and wakefulness in the rat.

Neuropharmacology
C DugovicP A Janssen

Abstract

The effects of risperidone, a new antipsychotic with potent 5-hydroxytryptamine2 (5-HT2) and dopamine-D2 (DA-D2) antagonistic properties, were studied on sleep-wakefulness patterns in rats. Administration of low doses (0.01-0.16 mg/kg i.p.) resulted in a significant increase of deep slow wave sleep (SWS2) and a decrease of wakefulness (W) and light slow wave sleep (SWS1). High doses (0.63-2.5 mg/kg) produced opposite effects. Paradoxical sleep (PS) was significantly reduced over the dose range tested. The increase of SWS2 after low doses of risperidone could be related to a predominant and potent 5-HT2 receptor blocking activity.

Citations

Mar 20, 1998·Journal of Clinical Pharmacology·J T CallaghanG V Kondraske
Feb 1, 1994·Psychopharmacology·A A MegensJ E Leysen
Dec 1, 1993·Pharmacology, Biochemistry, and Behavior·I PanockaM Massi
Jul 8, 1999·Biological Psychiatry·R J Salin-PascualM R Laurrabaquio
Apr 3, 2002·Psychiatry Research·Hidehisa YamashitaMasatsugu Nagao
Nov 5, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chintan ShahAnita Kablinger
May 9, 2009·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Daniel NeuOlivier Le Bon
Feb 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·R W Kerwin
Jan 8, 2021·Journal of Psychopharmacology·Gabriella NyitraiAndrás Czurkó

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