Differential effects of the novel antidepressant agomelatine (S 20098) versus fluoxetine on 5-HT1A receptors in the rat brain

Neuropharmacology
Naïma HanounLaurence Lanfumey

Abstract

Agomelatine (S 20098) is a novel antidepressant drug with melatonin receptor agonist and 5-HT(2C) receptor antagonist properties, but actual mechanisms underlying its antidepressant action are unknown. Because functional desensitization of 5-HT(1A) autoreceptors in the dorsal raphe nucleus (DRN) occurs after chronic administration of several classes of antidepressants, we investigated whether this adaptive change could also be induced by agomelatine. Neither acute nor chronic treatment with agomelatine (10 mg/kg i.p. for 14 days or 50 mg/kg i.p. for 21 days) changed the density of 5-HT(1A) receptors and their coupling with G proteins in the DRN and the hippocampus in rats. Moreover, these treatments did not affect the basal electrophysiological characteristics and the responses to 5-HT(1A) receptor stimulation of DRN and hippocampal neurons in brain slices. Parallel experiments with melatonin (10 mg/kg i.p. for 14 days) and fluoxetine (5 mg/kg i.p. for 14 days) as reference compounds showed that the former was unable to affect 5-HT(1A) receptors whereas the latter decreased both the 5-HT(1A) receptor-mediated [(35)S]GTP-gamma-S binding and the potency of ipsapirone, a 5-HT(1A) receptor agonist, to inhibit neuronal firing in the...Continue Reading

References

Apr 17, 1992·Journal of Medicinal Chemistry·S YousB Guardiola-Lemaitre
May 1, 1991·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·W H Strauss, E Klieser
Jul 1, 1994·Trends in Pharmacological Sciences·P Blier, C de Montigny
Apr 1, 1997·Neuropharmacology·G A KennettT P Blackburn
Jan 1, 1997·Acta Psychiatrica Scandinavica. Supplementum·R M Pinder
Aug 26, 1999·Japanese Journal of Pharmacology·K Ishihara, M Sasa
Mar 10, 2000·European Journal of Pharmacology·S ConwayP J Morgan
Nov 4, 2000·Expert Opinion on Investigational Drugs·V LeroyN P Peet
Apr 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·I C Reid, C A Stewart
Aug 22, 2001·Biological Psychiatry·N Haddjeri, P Blier
Apr 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julie G Hensler
Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mariusz PappElisabeth Mocaër
Dec 11, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark S KramerYih Lee

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Citations

May 23, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel Anthony JohnsonSarah Elizabeth Gartside
Aug 9, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Franck ChenuPierre Blier
Jan 27, 2006·International Clinical Psychopharmacology·Eberhard FuchsBarthel Schmelting
Nov 18, 2006·Behavioural Pharmacology·Valérie Bertaina-AngladeElisabeth Mocaër
Sep 1, 2007·Behavioural Pharmacology·Jessica A Valluzzi, KinHo Chan
Mar 23, 2010·International Clinical Psychopharmacology·Giorgio Racagni, Maurizio Popoli
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Laurent Descarries, Mustaph Riad
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·C A McClung
Feb 10, 2006·Expert Review of Neurotherapeutics·Céline FaureNasser Haddjeri
Dec 6, 2006·Expert Review of Neurotherapeutics·S R Pandi-PerumalM J Monti
Sep 17, 2013·Expert Opinion on Drug Safety·Enrico Smeraldi, Dario Delmonte
Mar 3, 2015·Expert Opinion on Investigational Drugs·Giulio PerugiNunzio Bucci
Jun 28, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·Luis San, Belen Arranz
Mar 31, 2007·Pharmacology & Therapeutics·Colleen A McClung
Dec 22, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nashat AbumariaGabriele Flügge
Aug 12, 2014·Human Psychopharmacology·Brian H Harvey, Francois N Slabbert
Apr 15, 2014·British Journal of Pharmacology·B Guardiola-LemaitreE Mocaër
Mar 3, 2010·Human Psychopharmacology·R H McAllister-WilliamsS Bazire
Apr 1, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Vikas KauraSarah J Judge
Feb 28, 2006·Biological Psychiatry·Mounira BanasrAnnie Daszuta
Sep 6, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jolanda TumaJaap M Koolhaas
Mar 28, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Maurizio PompiliPaolo Girardi
Dec 1, 2010·Behavioural Brain Research·Girstautė DagytėJaap M Koolhaas
Apr 9, 2011·The International Journal of Neuropsychopharmacology·Quentin RainerDenis J David
May 5, 2007·The International Journal of Neuropsychopharmacology·Jean Pierre Olié, Siegfried Kasper
Nov 27, 2008·The Annals of Pharmacotherapy·Christian R DolderMorgan Snider
Mar 4, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Siegfried Kasper, Michel Hamon
Oct 4, 2005·Médecine sciences : M/S·Elisabeth MocaërChristian de Bodinat
Feb 27, 2019·ACS Chemical Neuroscience·Kathryn G Commons, Sofia E Linnros

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