Differential effects of typical and atypical antipsychotics on nerve growth factor and choline acetyltransferase expression in the cortex and nucleus basalis of rats

Journal of Psychiatric Research
Vinay ParikhSahebarao P Mahadik

Abstract

Previously we reported that chronic exposure to haloperidol (HAL), but not the atypical antipsychotics risperidone (RISP) or clozapine (CLOZ), resulted in reductions in brain choline acetyltransferase (ChAT) immunoreactivity and impaired water maze task performance in rats. In the present study, we compared the effects of these antipsychotic drugs on the expression of nerve growth factor (NGF) as well ChAT the in the rat cortex and nucleus basalis of Meynert (NBM) in an effort to determine the underlying mechanism for the differential drug effects observed previously. We also evaluated the effects of these compounds in a crossover design to evaluate specific neurochemical consequences of switching between typical and atypical antipsychotics, a common practice observed in the clinical setting. Male Wistar rats (250-300 g) were exposed to HAL (2.0 mg/kg/day), RISP (2.5 mg/kg/day), or CLOZ (20 mg/kg/day) for 45 days or a pre-treatment regimen consisting of administering either RISP/HAL (i.e., RISP followed by HAL) or CLOZ/HAL, or a post-treatment regimen consisting of administering: HAL/RISP or HAL/CLOZ. The duration of each treatment in the crossover study was also 45 days. NGF and ChAT immunoreactivity were measured by quantitat...Continue Reading

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Citations

Dec 21, 2010·Psychopharmacology·Parichehr Hassanzadeh, Sina Rahimpour
Sep 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anilkumar PillaiSahebarao P Mahadik
Feb 9, 2012·Neurochemical Research·Parichehr Hassanzadeh, Anna Hassanzadeh
Feb 15, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Parichehr Hassanzadeh, Anna Hassanzadeh
Oct 22, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Benedicto Crespo-FacorroJosé L Vázquez-Barquero
Mar 16, 2007·Acta Psychiatrica Scandinavica·H A Nasrallah
Mar 30, 2016·Pharmacogenomics·Stefano PorcelliDan Rujescu
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Nov 18, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Melissa P DelBelloStephen M Strakowski
May 17, 2006·The Journal of Pharmacology and Experimental Therapeutics·Alvin V TerrySahebarao P Mahadik
Oct 17, 2008·Pharmacological Reviews·Jeffrey A LiebermanJohn G Csernansky
May 21, 2019·Frontiers in Psychiatry·Kristina NeugebauerThomas Nickl-Jockschat

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