Differential effects of vagus nerve stimulation strategies on glycemia and pancreatic secretions.

Physiological Reports
Sophie C PayneJoel Villalobos

Abstract

Despite advancements in pharmacotherapies, glycemia is poorly controlled in type 2 diabetic patients. As the vagus nerve regulates energy metabolism, here we evaluated the effect various electrical vagus nerve stimulation strategies have on glycemia and glucose-regulating hormones, as a first step to developing a novel therapy of type 2 diabetes. Sprague-Dawley rats were anesthetized, the abdominal (anterior) vagus nerve implanted, and various stimulation strategies applied to the nerve: (a) 15 Hz; (b) 4 kHz, or 40 kHz and; (c) a combination of 15 Hz and 40 kHz to directionally activate afferent or efferent vagal fibers. Following a glucose bolus (500 mg/kg, I.V.), stimulation strategies were applied (60 min) and serial blood samples taken. No stimulation was used as a crossover control sequence. Applying 15 Hz stimulation significantly increased glucose (+2.9 ± 0.2 mM·hr, p = .015) and glucagon (+17.1 ± 8.0 pg·hr/ml, p = .022), compared to no stimulation. Application of 4 kHz stimulation also significantly increased glucose levels (+1.5 ± 0.5 mM·hr, p = .049), while 40 kHz frequency stimulation resulted in no changes to glucose levels but did significantly lower glucagon (-12.3 ± 1.1 pg·hr/ml, p = .0009). Directional afferent ...Continue Reading

References

Feb 11, 1986·The American Journal of Physiology·B AhrénG J Taborsky
Sep 1, 1986·Journal of the Autonomic Nervous System·J J HolstO V Nielsen
Apr 1, 1987·The Journal of Clinical Investigation·S NishiH Imura
Dec 11, 1988·The American Journal of Physiology·B E DunningG J Taborsky
Apr 1, 1995·The British Journal of Radiology·N R MooreB J Britton
Oct 1, 1994·Journal of Diabetes and Its Complications·A D Harrower
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·H R Berthoud, W L Neuhuber
Jun 26, 2001·Annals of Emergency Medicine·R A HarriganP Beattie
Apr 3, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J RozmanB Zorko
Apr 13, 2005·Lancet·Michael StumvollTimon W van Haeften
May 6, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Henry A Spiller, Tama S Sawyer
May 17, 2008·Regulatory Peptides·Hans-Rudolf Berthoud
Aug 30, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Karen L Teff
Nov 11, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Michael CamilleriFrank G Moody
Dec 31, 2009·Diabetes Care·Jonathan B BrownGregory A Nichols
Sep 21, 2010·Experimental Neurology·Mark A CastoroWarren M Grill
Sep 14, 2012·Journal of Managed Care Pharmacy : JMCP·Craig I ColemanTawfikul Alam
Jan 31, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B BonazD Clarençon
Aug 9, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Kevin L Kilgore, Niloy Bhadra
Aug 31, 2013·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Luis-Emilio García-PérezDomingo Orozco-Beltrán
Feb 15, 2014·Nature Reviews. Drug Discovery·Amedeo VetereBridget K Wagner
Sep 4, 2014·JAMA : the Journal of the American Medical Association·Sayeed IkramuddinCharles J Billington
Aug 16, 2016·Patient Preference and Adherence·William H Polonsky, Robert R Henry
Jun 16, 2017·Journal of Research in Pharmacy Practice·Mansour SiavashNiloufar Razavi
Dec 9, 2017·Nature Reviews. Endocrinology·Yan ZhengFrank B Hu
Jul 4, 2018·Journal of Neural Engineering·P SennJ B Fallon
Sep 7, 2018·Nature Reviews. Gastroenterology & Hepatology·T M Zaved WaiseTony K T Lam
Nov 6, 2018·Nature Reviews. Gastroenterology & Hepatology·Sophie C PayneMartin J Stebbing
May 28, 2019·Frontiers in Neuroscience·Sophie C PayneJames B Fallon
Jun 22, 2019·Obesity Surgery·Jieyun YinJiande Dz Chen

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Citations

Aug 7, 2021·Frontiers in Neuroanatomy·Battuvshin LkhagvasurenYu-Min Kuo
Jan 7, 2022·Annual Review of Pharmacology and Toxicology·Zaman MirzadehMichael W Schwartz

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