Differential effects of various progestogens on metabolic risk factors for breast cancer

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Carlo CampagnoliClementina Peris

Abstract

Biological and epidemiological findings suggest that metabolic factors - insulin, insulin-like growth factor-I (IGF-I) and sex hormone-binding globulin (SHBG) - are involved in the development and promotion of breast cancer. Estrogens, particularly if administered orally, counteract metabolic factors that increase breast cancer risk, i.e. they reduce insulin and IGF-I and increase SHBG. This could contribute toward explaining epidemiological data showing that unopposed oral estrogens do not increase breast cancer risk, or do so only modestly. In contrast to natural progesterone and progesterone-derived progestins, progestins endowed with androgenic (or glucocorticoid) activity negatively influence these metabolic factors, counteracting the favorable effects of estrogens. While most biological and epidemiological findings suggest that natural progesterone does not augment breast cancer risk, available data show an increased risk with synthetic progestins - with the possible exception of progesterone-derived dydrogesterone. Different mechanisms for different progestins could possibly be involved. Differences from progesterone with regard to pharmacokinetics and pharmacodynamics, potency, interaction with the two isoforms of the p...Continue Reading

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Citations

May 13, 2010·Menopause : the Journal of the North American Menopause Society·Yayun LiangSalman M Hyder
Jan 3, 2009·Maturitas·Carlo CampagnoliClementina Peris
Nov 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Prakash ThangavelRossana C Zepeda

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