Differential effects of wake promoting drug modafinil in aversive learning paradigms

Frontiers in Behavioral Neuroscience
Bharanidharan ShanmugasundaramGert Lubec

Abstract

Modafinil (MO) an inhibitor of the dopamine transporter was initially approved to treat narcolepsy, a sleep related disorder in humans. One interesting "side-effect" of this drug, which emerged from preclinical and clinical studies, is the facilitation of cognitive performance. So far, this was primarily shown in appetitive learning paradigms, but it is yet unclear whether MO exerts a more general cognitive enhancement effect. Thus, the aim of the present study in rats was to extend these findings by testing the effects of MO in two aversive paradigms, Pavlovian fear conditioning (FC) and the operant two-way active avoidance (TWA) learning paradigms. We discovered a differential, task-dependent effect of MO. In the FC paradigm MO treated rats showed a dose-dependent enhancement of fear memory compared to vehicle treated rats, indicated by increased context-related freezing. Cue related fear memory remained unaffected. In the TWA paradigm MO induced a significant decrease of avoidance responses compared to vehicle treated animals, while the number of escape reactions during the acquisition of the TWA task remained unaffected. These findings expand the knowledge in the regulation of cognitive abilities and may contribute to the u...Continue Reading

References

Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·J R Blackburn, A G Phillips
Feb 24, 2001·Journal of Child and Adolescent Psychopharmacology·F B Taylor, J Russo
May 1, 2002·Clinical Neuropharmacology·Anette V Nieves, Anthony E Lang
Jun 8, 2002·European Psychiatry : the Journal of the Association of European Psychiatrists·Kenneth R KaufmanAdriana Fitzsimmons
Jan 22, 2004·Methods and Findings in Experimental and Clinical Pharmacology·D GetovaI Roukounakis
Apr 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Greg D GaleMichael S Fanselow
Apr 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Danielle C TurnerBarbara J Sahakian
Aug 11, 2004·Pharmacology, Biochemistry, and Behavior·Christopher P WardJohn G McCoy
Nov 4, 2004·Hippocampus·Robert E ClarkLarry R Squire
May 4, 2006·The Journal of Clinical Psychiatry·Jacob S Ballon, David Feifel
Aug 30, 2006·Neurobiology of Learning and Memory·Sandra SchäbleMichael Gruss
Aug 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael J Minzenberg, Cameron S Carter
Oct 16, 2007·Psychopharmacology·Daniel BéracochéaChristophe Piérard
Apr 1, 2009·Behavioral Neuroscience·Tristan ShumanStephan G Anagnostaras
Aug 31, 2010·Brain Research Bulletin·Héctor BurgosLuis Constandil
Oct 5, 2010·Pharmacology, Biochemistry, and Behavior·Christophe PierardDaniel Beracochea
Nov 26, 2010·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Tao GuoDong-Ya Xia
Mar 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ornella ValentiAnthony A Grace
Oct 19, 2011·Neuroscience Letters·Suzanne C Wood, Stephan G Anagnostaras
Jul 10, 2012·Neuropharmacology·Helaine A FernandesRoberto Frussa-Filho
Mar 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Justin M Moscarello, Joseph E LeDoux
Aug 21, 2013·Neuropharmacology·Vanessa Athaíde GarciaNadja Schröder
Dec 18, 2013·Pharmacological Reviews·Suzanne WoodStephan G Anagnostaras

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Ana Cristina TroncosoMarcus L Brandão
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
J L Miller
© 2021 Meta ULC. All rights reserved