Differential efficacy of biologic treatments targeting the TNF-α/IL-23/IL-17 axis in psoriasis and psoriatic arthritis

Cytokine
Kazuhisa FurueMasutaka Furue

Abstract

Psoriasis and psoriatic arthritis cause significant physical and psychological burdens for afflicted individuals. An accelerated TNF-α/IL-23/IL-17 axis is their major pathomechanism; therefore, anti-TNF-α/IL-23/IL-17 biologics are very effective for the treatment of skin and joint lesions in psoriasis and psoriatic arthritis. Given that the IL-17 signature is more upregulated in the skin than in synovium in psoriatic arthritis, anti-IL-23/IL-17 agents seem to be superior to anti-TNF-α remedies in the treatment of skin lesions. In this review, we focus on the differential efficacy of anti-TNF-α/IL-23/IL-17 biologics in psoriasis and psoriatic arthritis.

Citations

Dec 7, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Arshi KhanamShiv Kumar Sarin
Jan 17, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Kazuhisa FurueMasutaka Furue
Nov 7, 2019·Scandinavian Journal of Immunology·Kazuhisa FurueMasutaka Furue
Mar 24, 2020·PLoS Biology·Candelas Álvarez-SalameroMaría N Navarro
Jul 18, 2020·The Journal of Dermatology·Kazuhisa FurueMasutaka Furue
Apr 10, 2019·Journal of Leukocyte Biology·Ce TangYoichiro Iwakura
May 28, 2019·Innate Immunity·Masutaka Furue, Takafumi Kadono
Nov 7, 2019·International Journal of Molecular Sciences·Masutaka FurueGaku Tsuji
Feb 20, 2020·International Journal of Molecular Sciences·Masutaka FurueTakeshi Nakahara
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Feb 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaoxu WangGuangzhong Zhang
Apr 24, 2021·The Journal of Investigative Dermatology·Di YanWilson Liao

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