PMID: 2487642Jan 1, 1989Paper

Differential elasticity of the immature retina: a contribution to the development of the area centralis?

Visual Neuroscience
S T KellingB L Finlay

Abstract

Differential stretch of a retinal surface with an initially uniform cell density has been repeatedly implicated as one of the developmental mechanisms that produces the topographic organization of cell density in the adult retina, notably the area centralis or visual streak versus peripheral regions. It is known that intraocular pressure is required to produce the normal conformation and thinning of the retina during development. We tested the possibility that the retina has elastic properties that might permit differential stretch in conjunction with intraocular pressure. The relative deformation of the retina containing the presumptive area centralis was compared to the deformation of peripheral retina at equivalent applied fluid displacements in 7-12-day-old cats. The peripheral retina deformed significantly more, consistent with the hypothesis that differences in the local elasticities of the developing neural retina contribute to its characteristic topographic changes. Thus, a biomechanical property of the growing eye may contribute to the mechanism by which the pattern of the visual array is sampled.

References

Feb 1, 1987·Journal of Biomechanical Engineering·W WuM E Hammer
Apr 22, 1986·The Journal of Comparative Neurology·D R SengelaubB L Finlay
Jan 1, 1986·Vision Research·G W van Alphen
Jan 1, 1987·The Journal of Comparative Neurology·S R Robinson
Oct 1, 1984·The Journal of Comparative Neurology·D N MastronardeM W Dubin

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Citations

Sep 18, 2012·Progress in Retinal and Eye Research·Heidrun KuhrtHamid R Noori
Apr 1, 1991·Visual Neuroscience·R W Williams
Nov 1, 1992·Journal of Neurobiology·B L Finlay
Nov 11, 1996·The Journal of Comparative Neurology·B E ReeseG E Baker
Aug 14, 2020·Progress in Retinal and Eye Research·Jackson ScharfDavid Sarraf
May 15, 1991·The Journal of Comparative Neurology·M J Webster, M H Rowe
Jul 1, 1991·The Journal of Comparative Neurology·M M La VailP Rakic
Jul 8, 1989·The Journal of Comparative Neurology·K C WiklerB L Finlay
Jul 22, 1990·The Journal of Comparative Neurology·K C WiklerP Rakic

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