Differential enhancement of interferon-gamma-induced MHC class II expression of HEp-2 cells by 1,25-dihydroxyvitamin D3

The British Journal of Dermatology
K Tamaki, K Nakamura

Abstract

Interferon-gamma (IFN-gamma) induces the expression of MHC class II antigens on non-lymphoid cells. In this study we investigated the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the most active metabolite of vitamin D3, on the IFN-gamma-induced expression of MHC class II antigens on HEp-2 cells. We found that 1,25(OH)2D3 enhanced the IFN-gamma-induced expression of HLA-DR on these cells. Differential effects on the MHC class II antigens HLA-DR, -DQ and -DP were also observed.

References

Jan 1, 1985·Advances in Immunology·R C Giles, J D Capra
Aug 1, 1984·The Journal of Investigative Dermatology·T Y BashamV B Morhenn
Oct 1, 1984·The Journal of Clinical Investigation·W F RigbyM W Fanger
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E AbeT Suda

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