Differential enhancement of locomotor activity by dopamine agonists following chronic neuroleptic treatment: an animal model of tardive dyskinesia

European Journal of Pharmacology
N C TyeI A Pullar


Animals were administered clozapine or haloperidol for 22 days. Following treatment they were challenged with an apomorphine ester or lergotrile. Only haloperidol-treated animals exhibited significantly enhanced responses to apomorphine ester whereas administration of lergotrile potentiated locomotor activity in both treated groups. The results suggest that the use of different dopaminergic agonists may help to dissociate receptor supersensitivity arising from the antipsychotic actions of neuroleptics from that leading to the development of undesirable side effects.


Sep 1, 1984·Journal of the Autonomic Nervous System·J H PazoM A Dvorkin
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·G Kato, T Ban
Jul 31, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·H TakeuchiS Miura
Oct 3, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Laura Silveira-MoriyamaAndrew J Lees

Related Concepts

Dyskinesia, Medication-Induced
Antipsychotic Effect
Rats, Laboratory

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