Differential excretion of xenobiotic acyl-esters of carnitine due to administration of pivampicillin and valproate

Biochemical Medicine and Metabolic Biology
B MeleghL L Bieber

Abstract

The fate of supplemental carnitine was studied in human subjects treated with drugs known to cause carnitine deficiency. Six children were treated with pivampicillin and equimolar L-carnitine for 7 days. On the last day of treatment, the plasma levels of total and free carnitine were decreased, but acylcarnitine levels were increased. A 12-fold increase in urinary excretion of acylcarnitines was found; it increased from 188.5 +/- 82.7 to 2218.4 +/- 484.1 mumole/day, and 84% was pivaloylcarnitine. Free carnitine excretion was reduced. Ten epileptic children on chronic valproate treatment received equimolar carnitine for a 2-week period. Plasma carnitine levels were elevated on the last day of treatment. A 3.4-fold increase in urinary acylcarnitines was found, but most of the excreted carnitines were free (64.5-fold increases). These data show that pivalate is readily converted to carnitine esters, in contrast to the limited conversion of valproate to acylcarnitines in humans.

References

Jul 1, 1985·Neurology·D A StumpfC Angelini
Jun 1, 1985·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S VickersB H Arison

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Citations

Nov 16, 1995·Biochimica Et Biophysica Acta·Q N DiepT Bøhmer
Sep 25, 1992·Biochemical Pharmacology·Q N DiepL Schjerven
Jun 14, 2002·Journal of Pharmaceutical and Biomedical Analysis·Jørgen OlsenSteen Honoré Hansen
Apr 1, 1992·Antimicrobial Agents and Chemotherapy·K TotsukaS Yamamoto
May 1, 1993·Antimicrobial Agents and Chemotherapy·K ShimizuT Nishikawa
May 15, 2003·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J OlsenS Honorè Hansen
Nov 13, 2007·Journal of Neurochemistry·Dorota MieczKatarzyna A Nałecz
Apr 25, 2008·Expert Opinion on Drug Metabolism & Toxicology·Christian SkonbergMark P Grillo
Nov 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B MeleghA D Sherry
Sep 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·E HolmeI Nordin
Jun 23, 2009·Chemico-biological Interactions·Liliane TodescoStephan Krähenbühl
Feb 17, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jørgen OlsenSteen Honoré Hansen
Mar 16, 2004·Acta Neurologica Scandinavica·C-M LokrantzF Asztely
Apr 1, 1995·Metabolism: Clinical and Experimental·T L BroderickD J Paulson
Sep 1, 1991·Toxicology and Applied Pharmacology·L J Ruff, E P Brass

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