Differential expression and clinical significance of epithelial-mesenchymal transition markers among different histological types of triple-negative breast cancer

Journal of Cancer
Shuling ZhouWentao Yang

Abstract

Background: Triple-negative breast cancer (TNBC) is a heterogeneous disease closely associated with epithelial-to-mesenchymal transition (EMT). This study aimed to investigate the role of EMT in metaplastic carcinoma.Methods:E-cadherin, Slug, Twist and Vimentin levels were detected by immunohistochemistry in 167 TNBC tumors, including 145 invasive carcinomas of no special type (ICONSTs), 14 spindle cell carcinomas (SpCCs) and 8 matrix-producing carcinomas (MPCs).Results:Nuclear Slug and Twist were more frequently detected in SpCC and MPC tumors than that in ICONST tumors (p<0.001). The rate of E-cadherin loss was much lower in the ICONST tumors than that in the SpCC and MPC tumors (p<0.001). Vimentin was expressed in all SpCC and MPC tumors. Furthermore, nuclear expression of Slug and Twist was positively associated with the cytoplasmic localization of Vimentin (p<0.001) and was inversely associated with membranous staining of E-cadherin (p<0.001). These trends were more apparent in the SpCC and MPC tumors than in the ICONST tumors. Follow-up data were available for 151 patients. The follow-up times ranged from 1 month to 11 years (mean: 74 m; median: 21 m). The median progression-free survival and overall survival times were 2...Continue Reading

Citations

Apr 18, 2020·Breast Cancer Research and Treatment·Charlotte Levin Tykjær JørgensenLisa Rydén
Nov 30, 2018·Cancer Causes & Control : CCC·Chunyan HeThomas C Tucker
May 19, 2020·Biomedit︠s︡inskai︠a︡ khimii︠a︡·A I AutenschlyusV V Lyakhovich
Oct 8, 2020·Cancer Research·Adrián Blanco-GómezSonia Castillo-Lluva
May 1, 2021·Journal of Clinical Medicine·Marcin OpławskiDariusz Boroń
Jul 25, 2021·International Journal of Molecular Sciences·Silvia González-MartínezJosé Palacios

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BETA
biopsy
dissection

Software Mentioned

SPSS

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