PMID: 9546604Apr 18, 1998Paper

Differential expression and localization of annexin V in cardiac myocytes during growth and hypertrophy

Molecular and Cellular Biochemistry
S W JansM van Bilsen

Abstract

Recently it was shown that annexin V is the most prominent member of the annexin family in the adult heart [1]. Amongst others, annexin V has been suggested to play a role in developmental processes. The aim of the present study was to explore whether in the heart annexin V content and localization change during maturational and hypertrophic growth, in order to obtain indications that annexin V is involved in cardiac growth processes. First, in the intact rat heart annexin V content and localization were studied during perinatal development. It was clearly demonstrated that annexin V content in total heart transiently increased in the first week after birth, from 0.79 +/- 0.06 microg/mg protein at 1 day before birth to a peak value of 1.24 +/- 0.08 microg/mg protein 6 days after birth, whereafter annexin V protein levels declined to a value of 0.70 +/- 0.06 microg/mg protein at 84 days after birth (p < 0.05). Differences in annexin V content were also observed between myocytes isolated from neonatal and adult hearts [0.81 +/- 0.09 and 0.17 +/- 0.08 microg/mg protein, respectively (p < 0.05)]. Moreover, during cardiac maturational growth the subcellular localization of annexin V might change from a cytoplasmic to a more prominen...Continue Reading

Citations

Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·C J FriddleJ Bristow
Jun 29, 2004·Muscle & Nerve·Stefan Probst-CousinDieter Heuss
Oct 30, 2004·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·Stefan Probst-CousinDieter Heuss
Oct 25, 2008·The Open Cardiovascular Medicine Journal·Mohammad M DallakNoha A Afifi
Mar 14, 2014·Molecular Biology of the Cell·Travis A DittmerTom Misteli
Jul 18, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Keiichi IkedaMasahiro Kawamura
Mar 28, 2002·Physiological Reviews·Volker Gerke, Stephen E Moss
Mar 4, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·D BenevolenskyD Charlemagne

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