Differential expression and regulation of prostaglandin E synthases in the mouse ovary during sexual maturation and luteal development

The Journal of Endocrinology
Tong SunZeng-Ming Yang

Abstract

Prostaglandin (PGE) 2 is the most common prostanoid and plays an important role in female reproduction. The aim of this study was to examine the expression and regulation of microsomal (m) PGE synthase (PGES)-1 and cytosolic (c) PGES in the mouse ovary during sexual maturation, gonadotropin treatment and luteal development by in situ hybridization and immunohistochemistry. Both mPGES-1 mRNA signals and immunostaining were localized in the granulosa cells, but not in the thecal cells and oocytes. cPGES mRNA signals were localized in both granulosa cells and oocytes, whereas cPGES immunostaining was exclusively localized in the oocytes. In our superovulated model of immature mice, there was a basal level of mPGES-1 mRNA signals in the granulosa cells at 48 h after equine chorionic gonadotropin (eCG) treatment. mPGES-1 mRNA level was induced by human chorionic gonadotropin (hCG) treatment for 0.5 h, whereas mPGES-1 immunostaining was slightly induced at 0.5 h after hCG treatment and reached a maximal level at 3 h after hCG treatment. eCG treatment had no obvious effects on either cPGES mRNA signals or immunostaining. A strong level of cPGES immunostaining was present in both unstimulated and eCG-treated groups. Both mPGES-1 mRNA s...Continue Reading

Citations

Apr 16, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Fabienne NuttinckBénédicte Grimard
Jun 21, 2012·Molecular and Cellular Endocrinology·Katsumi TodaToshiji Saibara
Apr 7, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Anne JørgensenHenrik Leffers
May 31, 2015·Human Reproduction Update·Diane M Duffy
Jun 13, 2014·Biology of Reproduction·Ajay Pradhan, Per-Erik Olsson
Sep 20, 2007·Pharmacological Reviews·Bengt SamuelssonPer-Johan Jakobsson
Jul 16, 2014·Medicinal Research Reviews·Malkeet Singh BahiaPragati Silakari

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