Differential expression of a gene highly homologous to c-ras during the development of the brine shrimp Artemia

Biochemical and Biophysical Research Communications
M Díaz-GuerraJ Renart

Abstract

We report the identification of p21ras and a cDNA coding for it in the crustacean Artemia. The monoclonal antibody Y13-259 immunoprecipitates a polypeptide of 21.5 kDa in 24 hr-old larvae. The homology of p21ras with the Drosophila melanogaster and the mammalian p21s is in the order of 75-80% mRNA (of 1.2 kb in length) is already present in encysted gastrulae, and the levels increase, reaching a maximum before emergence. On the contrary, both the amount of p21ras and its GTP-binding activity are low prior to emergence and rises afterwards. These results suggest that p21ras expression is regulated post-transcriptionally, and that its function(s) is needed for post-hatching events, the more likely being the resumption of cell proliferation.

References

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Citations

Jan 25, 2008·In Vitro Cellular & Developmental Biology. Animal·Guo-Bin HuKun-Feng Yang
Dec 1, 2009·PloS One·Takehiko OguraTakahiro Shiotsuki
Mar 26, 2003·The Journal of Experimental Biology·Ana Martinez-LampareroLeandro Sastre
May 15, 1991·Biochemical and Biophysical Research Communications·G T DrivasM G Rush

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