Differential expression of a zinc finger-encoding gene in response to positive versus negative signaling through receptor immunoglobulin in murine B lymphocytes.

Molecular and Cellular Biology
V L SeyfertJ G Monroe

Abstract

Egr-1 is a murine early growth factor-inducible gene that encodes a protein with zinc fingers and that is believed to be involved in transcriptional regulation. Expression of this gene was investigated in murine B lymphocytes stimulated through their receptor for antigen (surface immunoglobulin [sIg]) with antireceptor antibodies (anti-sIg). Rapid (by 15 min) up-regulation of Egr-1 mRNA expression was observed after sIg cross-linking at a dose of anti-sIg sufficient to drive the majority of cells into cell cycle. Interestingly, signaling through sIg on the murine B-lymphoma cell line WEHI-231 did not up-regulate Egr-1 expression even though similar signaling pathways, including up-regulation of c-fos expression, are associated with this receptor in these cells. Importantly, cell growth and proliferation of WEHI-231 cells were inhibited by anti-sIg stimulation, which suggested a relationship between Egr-1 expression and differential processing of receptor immunoglobulin signals with respect to cellular growth responses. This notion was further supported by the finding that murine B lymphomas whose proliferation was not inhibited by anti-sIg showed receptor immunoglobulin-coupled Egr-1 expression. In further support of this assoc...Continue Reading

References

Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·U HämmerlingJ Abbott
Aug 18, 1988·Nature·W W LamphI M Verma
May 1, 1988·Molecular and Cellular Biology·J M AlmendralR Bravo
Jul 1, 1986·The Journal of Experimental Medicine·P C Isakson
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L J JosephV P Sukhatme
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K RyderD Nathans
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L F Lau, D Nathans
Sep 1, 1986·The Journal of Experimental Medicine·E C SnowS Zimmer
Nov 27, 1980·Nature·J M Teale, N R Klinman
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J E McCormackG E Sonenshein
May 1, 1982·The Journal of Experimental Medicine·A L DefrancoW E Paul

❮ Previous
Next ❯

Citations

Apr 1, 1993·Immunological Reviews·E BaixerasC Martínez
Sep 1, 1994·The Journal of Allergy and Clinical Immunology·M MayumiK M Kim
Feb 28, 1991·Biochemical and Biophysical Research Communications·J F TilzeyT L Rothstein
Jun 1, 1991·Immunology Today·J E Alés-MartínezD W Scott
Oct 27, 2006·The Journal of Biological Chemistry·Jiyuan KeSubbarao Bondada
Apr 28, 1995·The Journal of Biological Chemistry·S L LeeJ Milbrandt
Mar 24, 1995·The Journal of Biological Chemistry·E J KilbourneS K Karathanasis
Nov 5, 1997·The Journal of Biological Chemistry·S MuthukkumarS Bondada
May 25, 2004·Infection and Immunity·M M M Abdel-LatifD Kelleher
Feb 1, 1995·Immunology and Cell Biology·A R Gottschalk, J Quintáns
Dec 22, 1995·The Journal of Biological Chemistry·N SakataE W Gelfand
Sep 21, 2004·World Journal of Gastroenterology : WJG·Cong-Mei WuTian-Hua Huang
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Murali GururajanSubbarao Bondada
Aug 1, 1993·European Journal of Immunology·A R GottschalkJ Quintáns
Oct 1, 1991·The American Journal of Physiology·D M CohenS R Gullans
Nov 1, 1991·Immunology Letters·L Fesus
Jul 1, 1989·Molecular Immunology·J G MonroeN Sykes
Feb 1, 1990·Seminars in Arthritis and Rheumatism·S YoshidaM E Gershwin

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