Differential expression of acidic and basic fibroblast growth factors in benign prostatic hyperplasia identified by immunohistochemistry

British Journal of Urology
N DeshmukhChristopher S Foster

Abstract

To detect the expression and to determine the relative cellular locations of the two peptide growth factors, acidic fibroblast growth factor (a-FGF) and basic (b)-FGF in tissues from human benign prostatic hyperplasia (BPH). A series of 50 sequential and unselected cases of human BPH tissues, obtained after transurethral prostatectomy, was examined. Adjacent sections of formalin-fixed and paraffin wax-embedded tissues were stained immunohistochemically for expression of a-FGF and b-FGF using well-characterized and commercially available antibodies. The stained tissue sections were assessed for the cellular distribution of immunohistochemical products and analysed according to the relative intensity of staining as well as the spatial relationships of positively stained cells. Acidic-FGF was weakly expressed with a pancytoplasmic distribution within luminal glandular epithelial cells in regions of prostatic intra-epithelial neoplasia (both PIN I and II) but not by non-dysplastic normal or hyperplastic tissues. No expression of a-FGF was detected in basal epithelial cells or in the stromal compartment of any tissue examined. In contrast, b-FGF was strongly expressed within the cytoplasm of all basal epithelial cells, but not by lu...Continue Reading

Citations

Oct 13, 2005·Virchows Archiv : an International Journal of Pathology·Karsten GravdalLars A Akslen
Dec 21, 2006·International Urology and Nephrology·Gulsah KaygusuzOrhan Gogus
Jun 11, 2009·International Journal of Andrology·B FibbiM Maggi
Dec 7, 2005·International Journal of Cancer. Journal International Du Cancer·Shiva S ForootanYouqiang Ke
Nov 1, 2000·The Prostate. Supplement·C S Foster
Jul 13, 2002·The Journal of Pathology·C S FosterY Ke
Jan 12, 2000·The Journal of Pathology·T J DorkinH Y Leung

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