PMID: 8594891Dec 1, 1995Paper

Differential expression of alpha- and beta-enolase genes during rat heart development and hypertrophy

The American Journal of Physiology
A KellerM Lucas

Abstract

We have analyzed the transition between isoforms of the glycolytic enzyme enolase (2-phospho-D-glycerate hydrolyase; EC 4.2.1.11) in rat heart during normal and pathological growth. A striking fall in embryonic alpha-enolase gene expression occurs during cardiac development, mostly controlled at pretranslational steps. In fetal and neonatal hearts, muscle-specific beta-enolase gene expression is a minor contributor to total enolase. Control mechanisms of beta-enolase gene expression must include posttranscriptional steps. Aortic stenosis induces a rapid and drastic decrease in beta-enolase transcript level in cardiomyocytes, followed by the fall in beta-subunit level. In contrast, alpha-enolase transcript level is not significantly altered, although the corresponding subunit level increases in nonmuscle cells. We conclude that, like fetal heart, hypertrophic heart is characterized by a high ratio of alpha- to beta-enolase subunit concentrations. This study indicates that the decrease in beta-enolase gene expression may be linked to beneficial energetic changes in contractile properties occurring during cardiac hypertrophy.

Citations

Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Hon Sing LeongMichael F Allard
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·T MerkulovaM Lucas
Aug 19, 2000·American Journal of Physiology. Endocrinology and Metabolism·M F AllardG P Bondy
Aug 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher E MascioJeffrey L Segar
May 12, 2015·BioMed Research International·Li-Yen R HuAikaterini Kontrogianni-Konstantopoulos
Aug 3, 1999·European Journal of Biochemistry·M NozaisM Lucas
Sep 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Abdelrahman Ibrahim AbushoukMohamed M Abdel-Daim
Oct 7, 2006·Free Radical Biology & Medicine·Yumin ChenDaret K St Clair

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