Differential expression of angiogenic and vasodilatory factors by invasive trophoblast giant cells depending on depth of invasion

Developmental Dynamics : an Official Publication of the American Association of Anatomists
M HembergerJ C Cross

Abstract

The uterine bed undergoes remarkable changes during pregnancy, including proliferation and decidualization of the uterine stroma and remodeling and angiogenesis of the maternal vasculature. Fetal-derived trophoblast giant cells invade into the uterus where they gain access to the maternal blood circulation to ensure sufficient nutrient supply of the embryo. In serial sections through early- to mid-gestation conceptuses, we have determined the exact distance of trophoblast invasion and the expression of angiogenic, vasodilatory, and anticoagulative factors that are likely to influence remodeling and redirection of the maternal circulatory system. Trophoblast derivatives were detected at a distance as far as approximately 300 microm from the placental border, where they are allocated exclusively along the mid-line of the decidua. The farthest invading cells characteristically expressed proliferin and proliferin-related protein, hormones that affect endothelial cell migration and vascularization. Occasionally, these cells replaced the normal vascular endothelium and acquired a "pseudo-endothelial" shape. Complete vascular disintegration was observed 50-80 microm outside of the placental border where maternal blood was entirely lin...Continue Reading

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Citations

Oct 8, 2005·Angiogenesis·Berthold Huppertz, Louis L H Peeters
Dec 12, 2012·Angiogenesis·Gabriela BarrientosSandra M Blois
Jul 10, 2007·Journal of Assisted Reproduction and Genetics·Donald S TorryRonald J Torry
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Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zofia MadejaMyriam Hemberger
Sep 16, 2010·BMC Developmental Biology·Lindsey N KentMichael J Soares
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Jan 9, 2016·Cell Adhesion & Migration·Juneo F Silva, Rogéria Serakides
Feb 26, 2013·Journal of Reproductive Immunology·Myriam Hemberger
May 15, 2012·Reproductive Biomedicine Online·Rosalind John, Myriam Hemberger
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