Differential expression of apolipoprotein-D and prostate specific antigen in benign and malignant prostate tissues

The Journal of Urology
J O AspinallW D Tilley

Abstract

To investigate Apolipoprotein-D (Apo-D) and prostate specific antigen (PSA) immunohistochemical staining of nonmalignant and malignant human prostate tissues. Apolipoprotein-D and PSA immunoreactivity were evaluated by video image analysis in nonmalignant prostates and in 30 stage D2 prostate cancers. Apolipoprotein-D was detected in all 30 tumors, and the level of staining was elevated in comparison to age-matched nonmalignant prostates (p < 0.05). In contrast, the level of PSA staining in tumors was less than that detected in nonmalignant prostates. Apolipoprotein-D is expressed in normal human prostate. Elevated Apo-D staining is associated with advanced prostate cancer.

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Citations

Oct 13, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·F SatohR Y Osamura
Mar 12, 2008·Breast Cancer Research and Treatment·Håvard SøilandJon Arne Søreide
Nov 4, 2000·Biochimica Et Biophysica Acta·E RassartR Milne
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Oct 3, 1999·The British Journal of Surgery·C Serra DíazJ Medrano

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