Differential expression of aquaporin 5 and aquaporin 3 in squamous cell carcinoma and adenoid cystic carcinoma

International Journal of Oncology
Shunsuke IshimotoYoshinori Kamisaki

Abstract

Aquaporins (AQPs) are a membrane protein family involved in the selective transport of water across cell membranes. Recent studies have reported the expression of AQP5 in several tumor types such as gastric, pulmonary, ovarian, pancreatic and colorectal cancer. We have previously reported the expression on tumor cells and the important role of AQP3 on cell growth in tongue cancer. However, little is known about the expression and precise role of AQP5 on squamous cell carcinoma (SCC) of the tongue. We investigated the expression of AQP5 and AQP3 in human oral SCC and adenoid cystic carcinoma (ACC). Overexpression of both AQP5 and AQP3 were immunohistochemically observed on tumor cells in SCC, whereas ACC cells were faintly stained with those antibodies against AQPs. Treatment with pan-AQP inhibitor or specific AQP5-siRNA showed inhibition of cell growth in SCC cell lines via the inhibition of integrins and the mitogen-activated protein kinase pathway. AQPs play important roles in cell growth in SCC rather than ACC.

Citations

Nov 14, 2013·BioMed Research International·Xiaodong GuoYuejuan Gao
Feb 4, 2016·Cellular and Molecular Life Sciences : CMLS·Inês DireitoGraça Soveral
Sep 11, 2014·Biochimica Et Biophysica Acta·Marios C Papadopoulos, Samira Saadoun
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Feb 2, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Qing LiHongzhi Sun
Aug 3, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Chatchaphan UdompatanakornKou Matsuo
Jul 8, 2020·Cells·Claudia D'AgostinoChristine Delporte
Feb 23, 2020·International Journal of Molecular Sciences·Mérin Barbara StamboniCláudia Malheiros Coutinho-Camillo
Apr 3, 2021·Frontiers in Genetics·Abul Kalam AzadParveen Afroz Chowdhury

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