PMID: 8939453Oct 1, 1996Paper

Differential expression of c-fos mRNA in rat prefrontal cortex, striatum, N. accumbens and lateral septum after typical and atypical antipsychotics: an in situ hybridization study

Neurochemistry International
J SembaS Kito

Abstract

The regional difference in the expression of c-fos mRNA induced by typical and atypical antipsychotics was determined in prefrontal cortex, striatum, N. accumbens and lateral septum in rats by in situ hybridization. Two typical antipsychotics, haloperidol (2 mg/kg) and fluphenazine (2 mg/kg), and three atypical antipsychotics, (-)sulpiride (100 mg/kg), clozapine (20 mg/kg) and OPC-14597 (40 mg/kg), were used. Brains were fixed with 4% paraformaldehyde 45 min after drug administration (i.p.). Brain sections of 30 microns-thickness were made in a cryostat and hybridized with 35S-labelled for c-fos oligonucleotide probe. These sections were apposed to X-ray films and the autoradiograms were semi-quantitatively analysed by computer-assisted densitometry. All antipsychotics used increased c-fos mRNA expression in N. accumbens shell, a region of the forebrain associated with limbic systems. On the other hand, two typical antipsychotics (haloperidol and fluphenazine) that cause a high incidence of acute motor side effects increased the expression of c-fos mRNA in the dorsolateral striatum, an extrapyramidal region primarily involved in motor control. Only clozapine induced c-fos mRNA in the medial prefrontal cortex and lateral septum....Continue Reading

References

Sep 1, 1992·Brain Research Bulletin·P Rogue, G Vincendon
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T V NguyenS E Hyman
Apr 1, 1990·Journal of Neurochemistry·J C Miller
Nov 21, 1994·Neuroscience Letters·A Fink-Jensen, P Kristensen
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M Merchant, D M Dorsa

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Citations

Jul 16, 1997·European Journal of Pharmacology·M PalkovitsE J Horváth
Jun 5, 1998·Trends in Pharmacological Sciences·M S LidowP S Goldman-Rakic
Sep 2, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·M TremblayD Lévesque
Sep 5, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M M MarcusT H Svensson
Nov 21, 1998·The European Journal of Neuroscience·P O TremblayC Rouillard
Jun 21, 2001·Neuroreport·E A RobinetP J Pauwels
Feb 17, 2009·European Journal of Pharmacology·Yoshihiro TadoriTetsuro Kikuchi
Aug 7, 2004·Brain Research. Brain Research Reviews·Teige P SheehanDavid S Russell
Dec 25, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Janitza L Montalvo-OrtizHongxin Dong
Nov 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mao-Liang Chen, Chia-Hsiang Chen
Aug 7, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yves ClaustreBernard Scatton
Apr 14, 2021·Neuroscience and Biobehavioral Reviews·Hannah S Wirtshafter, Matthew A Wilson

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