PMID: 8593259Nov 1, 1995Paper

Differential expression of calcyclin and its accessible ligands in various types of cutaneous tumors

Journal of Dermatological Science
U BrinckH Berger

Abstract

Calcyclin is the product of a gene that is regulated in dependence of the cell cycle in fibroblasts in vitro. It has recently been proven to be a sialic acid-binding protein in vitro and in the case of mammalian tissues to bind specifically to annexin II, annexin VI, annexin XI, and glyceraldehyde-3-phosphate dehydrogenase in a Ca(2+)-dependent manner. Since calcyclin can be labelled without impairment of its binding activity, it can be employed as a histochemical tool to localize its accessible ligands. Concomitantly, immunohistochemical localization of calcyclin with a specific antibody is warranted. By using histochemical and immunohistochemical techniques, the expression of calcyclin and its accessible binding sites are demonstrated in serial sections of normal skin and benign, pre-cancerous and malignant tumors of the skin, namely in verruca vulgaris, papillary hidradenoma, syringoma, keratoacanthoma, Bowen's disease, squamous cell carcinoma, melanocytic naevi, primary and metastatic malignant melanoma and non-Hodgkin lymphoma (NHL) of the skin. Cytoplasmic and nuclear expression of calcyclin and its ligands is unexceptionally found in normal skin, epithelial tumors and benign melanocytic tumors. Presence of calcyclin and ...Continue Reading

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Citations

Jul 15, 1997·Biochemical Pharmacology·F GhezzoF Di Carlo
Mar 29, 2001·Differentiation; Research in Biological Diversity·X SunA Hjerpe
Mar 26, 2003·The American Journal of Dermatopathology·Adriana Ribé, N Scott McNutt
May 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G N BertaF Di Carlo
Sep 27, 2015·Biochimica Et Biophysica Acta·Wiesława Leśniak, Agnieszka Graczyk-Jarzynka
Jan 19, 2008·Journal of Cutaneous Pathology·Douglas R FullenDafydd Thomas
Jan 15, 2008·Journal of Cutaneous Pathology·Puja Kumari PuriDirk Elston
Aug 5, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Munir H Idriss, Dirk M Elston
Jul 16, 2003·Biochemical and Biophysical Research Communications·Joung Hyuck JooIn Seong Choe
Nov 7, 2009·Biochemical and Biophysical Research Communications·Wiesława LeśniakAnna Filipek
Dec 3, 2014·The International Journal of Biochemistry & Cell Biology·Agnieszka Graczyk, Wiesława Leśniak
Oct 26, 1999·The Journal of Biological Chemistry·T B Stradal, M Gimona
Jun 13, 2001·Journal of Cutaneous Pathology·D R FullenN S McNutt

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