PMID: 2101599Dec 1, 1990Paper

Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis

Gut
M Y ChoyT T MacDonald

Abstract

Many interleukin-2 receptor (CD25) bearing cells can be identified by alkaline phosphatase immunohistochemistry in the diseased intestinal lamina propria of children with Crohn's disease or ulcerative colitis, but rarely in normal intestine. In both diseases, the CD25+ cells are present as aggregates in the lamina propria below the epithelium, and constitute a large proportion of the lamina propria mononuclear cells. In Crohn's disease, but not ulcerative colitis, CD25+ cells are abundant in the submucosa. The CD25+ cells in Crohn's disease are 58-88% CD3+, CD4+, CD8-, indicating that they are T cells, whereas in ulcerative colitis the CD25+ cells are greater than 80% CD3-, CD4+, HLA-DR+, indicating that they are macrophages. Thus, differential expression of CD25 on T cells and macrophages serves to distinguish the immunologic lesions in ulcerative colitis and Crohn's disease.

References

Apr 1, 1988·The Journal of Experimental Medicine·T T MacDonald, J Spencer
Oct 1, 1988·Gut·T T MacDonaldJ Spencer
Nov 20, 1987·Science·J C Weill, C A Reynaud
Oct 1, 1983·The Journal of Cell Biology·M E Zavala, D L Brandon
Jan 9, 1982·British Medical Journal·S K ChongJ A Walker-Smith

❮ Previous
Next ❯

Citations

Oct 1, 1995·Inflammatory Bowel Diseases·S A RademaS J van Deventer
Jan 1, 1997·Springer Seminars in Immunopathology·P BrandtzaegJ Rugtveit
Mar 14, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Alessio AnnovazziAlberto Signore
Dec 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·T T MacDonaldE J Breese
Aug 14, 1993·Lancet·F Shanahan
Jun 1, 1997·Journal of Virological Methods·M ArivananthanS Kumar
Aug 1, 1995·Trends in Microbiology·D V AblashiJ A DiPaolo
Jul 10, 2003·Autoimmunity Reviews·Robert M Craig
Nov 1, 2000·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·T MatsuuraC Fiocchi
Aug 1, 1993·Immunology and Cell Biology·B R Yacyshyn
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Earl GillespieJames M Becker
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·D G ForcioneS Pillai
Aug 6, 1999·The American Journal of Surgical Pathology·G OberhuberM Stolte
Aug 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·D A BrossA Bousvaros
Sep 1, 1996·Journal of Gastroenterology and Hepatology·H SerizawaH Ishii
Oct 1, 1994·Periodontology 2000·J R Kalmar
Apr 1, 1994·Acta Paediatrica. Supplement·C P Braegger
Feb 1, 1995·Acta Paediatrica·K N ChanT T MacDonald
May 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S KontiainenL Halme
May 1, 1993·Archives of Disease in Childhood·T T MacDonald
Apr 1, 1991·Gut·Y R Mahida
Nov 1, 1994·Gut·N MahmudD Kelleher
Mar 1, 1994·Gut·L BeaugerieY Le Quintrec
Nov 1, 1995·Gut·L BeaugerieN Brousse
Nov 1, 1991·Journal of Clinical Pathology·J SpencerT T MacDonald
Nov 1, 1994·Journal of Clinical Pathology·R KarttunnenT T MacDonald
Jan 1, 1993·Mediators of Inflammation·O H Nielsen, J Brynskov
Jan 1, 1994·Mediators of Inflammation·G Radford-Smith, D P Jewell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.