PMID: 8599448Oct 1, 1995Paper

Differential expression of CD44 in malignant cutaneous epithelial neoplasms

The American Journal of Dermatopathology
V G PrietoC R Shea

Abstract

The CD44 antigen (ECMRIII, Hermes antigen) is a highly glycosylated cell-surface polypeptide involved in diverse cellular functions, including cell adhesion and lymphocyte-homing receptor activity. CD44 is also expressed in vivo by several tumors, including astrocytomas, meningiomas, and colonic adenocarcinomas. In addition, it has been shown that expression of CD44 appears to confer metastatic potential to cell lines derived from certain adenocarcinomas. In the skin, CD44 is normally expressed in epidermal keratinocytes and hair follicular, sebaceous, and eccrine epithelial cells. However, there have been few data with regard to the expression in vivo of CD44 in primary cutaneous neoplasms. Furthermore, there have not been studies in vivo of the possible differential expression of CD44 in primary versus metastatic tumors in the skin. We have examined by immunohistochemistry the expression of CD44 in cutaneous invasive and metastatic squamous cell carcinomas, metastatic adenocarcinomas, and basal cell carcinomas. All invasive and metastatic squamous cell carcinomas, as well as metastatic adenocarcinomas, strongly expressed CD44; however, basal cell carcinomas were nonreactive or showed only focal, minimal reactivity. Adjacent n...Continue Reading

Citations

Jul 1, 1997·Journal of Cutaneous Pathology·C H OrteuS J Whittaker
Sep 21, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·T G TzellosE Papakonstantinou
Aug 8, 1998·Journal of Cutaneous Pathology·T IchikawaS Taniguchi
Jan 22, 2003·The British Journal of Dermatology·S KarvinenR Tammi
Dec 1, 1996·Seminars in Cutaneous Medicine and Surgery·D Mehregan, D Mehregan
Feb 3, 2000·Archives of Pathology & Laboratory Medicine·L R YlaganR Demopoulos

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