PMID: 3770994Nov 15, 1986Paper

Differential expression of cellular oncogenes in benign and malignant human breast tissue

International Journal of Cancer. Journal International Du Cancer
J L WhittakerJ M Varley

Abstract

We have examined 62 specimens of benign fibrocystic breast tissue, fibroadenomas, carcinomas and surrounding non-malignant tissue excised from 50 patients to determine the level of expression of 4 cellular oncogenes, c-myc, c-H-ras, c-K-ras, and c-N-ras. Our results demonstrate that in breast carcinoma the frequency and relative level of expression of these oncogenes are significantly greater than those found for benign breast tissue. However, some fibrocystic specimens having prominent hyperplastic features also exhibited enhanced oncogene expression. In view of the association between the increased frequency of carcinoma of the breast in women with a previous history of benign breast disease, it will be interesting to follow up donors of benign specimens to see if there is any relationship between the expression of oncogenes in such lesions and the development of carcinomas.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·B E NoyesK L Agarwal
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·G E GallickJ U Gutterman
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M H KrausS A Aaronson
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P H HandJ Schlom
Jan 28, 1984·British Medical Journal·M M RobertsI H Gravelle
Apr 20, 1984·Science·D J SlamonM J Cline

❮ Previous
Next ❯

Citations

Dec 1, 1993·Journal of Surgical Oncology·D J HehirM P Brady
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·Z P PavelicL Pavelic
Jan 1, 1991·Breast Cancer Research and Treatment·D M WatsonW R Miller
Jan 1, 1996·Pathology Oncology Research : POR·John S McDonaldZlatko P Pavelic
Jul 1, 1992·European Journal of Cancer. Part B, Oral Oncology·J K Field
Jan 7, 1999·Breast Cancer Research and Treatment·C Lundin, F Mertens
Sep 1, 1987·Journal of Clinical Pathology·V T Chan, J O McGee
Jan 31, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rena LymbouridouDemetrios A Spandidos
Mar 1, 1988·Cancer Treatment Reviews·R J Epstein
Sep 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J S McDonaldJ L Gluckman
Jan 1, 1992·Journal of Cellular Biochemistry. Supplement·N T TelangM P Osborne
Jan 1, 1990·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·J MackayC M Steel
Apr 1, 2017·Journal of Genetics·Samira SadeghiHossein Tabatabaeian
Dec 10, 1991·Biochimica Et Biophysica Acta·S J McKenzie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.